Regarding percentage dissolution efficiency, there was fourfold increment in %DE from LSA 15 compared to conventional tablets. It was found that the %DE is always (with both R-values and all liquid vehicles used) higher from liquisolid check details tablets with lower drug concentration. The less drug concentration

in the vehicle means more fraction of the drug is liable to be in the liquid solution form (i.e., Inhibitors,research,lifescience,medical molecularly dispersed), which is a prerequisite for fast drug dissolution. Moreover, the more vehicle available means an even distribution of the vehicle over the remaining undissolved drug particles that will help in good wetting of the drug during the dissolution step. From the results of different batches prepared by three different carriers shown in Table 6, it was found that Neusilin proved to be the superior carrier than others. Fujicalin, also to some extent, proved to be a better

carrier than Avicel. The pronounced effect of the different carriers was not observed on dissolution profile so the flow properties and tensile strength were considered Inhibitors,research,lifescience,medical for optimizing the carrier. A lesser amount of Neusilin was required to adsorb the same amount of liquid vehicle than Avicel and Fujicalin, which Inhibitors,research,lifescience,medical lowered the weight of tablet. The flow property obtained by Neusilin was good and remains unaffected at such low amount. The tensile strength of the tablet was also sufficient. The flowability improvement can be attributed to the high porosity and high specific surface area of these Inhibitors,research,lifescience,medical excipients, which allows penetration of liquid into the particle pores resulting in a weight gain of individual particle accompanied by better flow properties. Table 6 Comparison of carriers by different

parameters. 4. Conclusion Acrysol EL 135 proved to be promising liquid vehicle for formulation of liquisolid preparations. Inhibitors,research,lifescience,medical Olmesartan liquisolid tablets formulated from 80% w/w Acrysol EL 135 to the drug was found to be superior in terms of dissolution properties in comparison with other liquisolid formulations. Fujicalin and Neusilin are used as carrier materials instead of Avicel, the liquid adsorption Idoxuridine capacity increases by many folds. Thus, tablet weights are reduced in case of Fujicalin and Neusilin in comparison to commonly used carrier materials like Avicel. Conflict of Interests The authors certify that there is no conflict of interests with any financial organization regarding the material discussed in the paper. Acknowledgments The authors are very thankful to Alembic Pharmaceutical Limited, Vadodara (India), Abitec Corporation (USA), Gattefosse (France), Fuji Chemicals (Japan), and Corel Pharma (India) for providing gift samples.
Open-angle glaucoma, the most common form of glaucoma, accounts for at least 90% of all glaucoma. It is caused by clogging of Schlemm’s canal, develops slowly, and has a wide angle between iris and cornea. Its symptoms and damage are unnoticeable and it is a lifelong condition.