05). In comparison with the normocholesterolemic diet group, serum levels available of TC, LDL-C, SGOT, and HDL-C were elevated in the sesame seed containing diet group (P > 0.05). Rabbits supplemented with sesame oil (5%) were found to have lower circulating concentrations of TC, LDL-C, HDL-C, SGOT, and SGPT (P < 0.05), whilst concentrations of TG, apo A, apo B, insulin, and glucose remained unaltered compared to the hypercholesterolemic diet group (P > 0.05). Comparison of sesame oil versus normocholesterolemic diet groups revealed an elevation of triglycerides and reduction in apo A concentrations in the sesame oil fed group (P < 0.05). None of the evaluated biochemical parameters did significantly differ between sesame seed and sesame oil supplemented groups (P > 0.05).4.

DiscussionFindings of the present study suggested that dietary supplementation with sesame oil significantly reduces TC and LDL-C concentrations in rabbits under a lipogenic diet. These findings are consistent with those of previous studies. Visavadiya and Narasimhacharya [30] examined the effects of supplementation with sesame seed powder at 5% and 10% doses along with either normal or hypercholesterolemic diet for a period of 4 weeks. Administration of sesame seed powder to hypercholesterolemic rats resulted in a significant decline in plasma and hepatic total lipid and cholesterol, and plasma LDL-C whilst increasing HDL-C concentrations. In another investigation to evaluate hypocholesterolemic and antioxidant activity of sesame protein isolate, Biswas et al.

[31] fed 18% sesame protein isolate with or without 2% cholesterol in comparison with casein to rats for 28 days. The results revealed that dietary sesame protein isolate reduces plasma total cholesterol, triacylglycerol, and LDL-C, increases HDL-C, and mitigates lipid peroxidation in both hypercholesterolemia and normocholesterolemic diet groups. Sirato-Yasumoto and associates demonstrated that supplementation with lignan-rich sesame Anacetrapib has a remarkable potentiating effect on hepatic fatty acid oxidation while downregulating the activity of lipogenic enzymes. These favorable metabolic effects of lignan-rich sesame were reported to be accompanied with a profound hypotriglyceridemic effect [32]. In a recent report, Asgari et al. [25] investigated the protective effects of sesame on postprandial lipemic and glycemic response as well as circulating concentrations of endothelial function biomarkers in hypercholesterolemic rabbits. Their results revealed that sesame supplementation is associated with significant declines in serum TC, LDL-C, SGPT, and fibrinogen. In the study by Kumar et al.