It is generally accepted that children with West syndrome who have evidence of pre-existing developmental delay or neurological abnormalities have a worse prognosis with a poorer response to treatment and less favorable developmental outcome [4]. However, children with Down syndrome and West syndrome seem to have a better prognosis compared to other patients with symptomatic infantile spasms with a better control of clinical spasms, and early initiation of appropriate treatment

may contribute to the prevention of late seizure development and better developmental outcome [1], [2] and [20]. Conflicting results have been published regarding the role of diagnostic delay and/or treatment lag in the outcome

of infantile spasms [9]. It was reported in a study that in CH5424802 chemical structure children with Down syndrome, a time less than 2 months prior to diagnosis of infantile spasms is associated with rapid control of spasms and better psychomotor development [17], while another study including infants with cryptogenic infantile spasms reported that a delay less than one month in diagnosing infantile spasms was important for the outcome [21]. Recently, it has been shown that the response to treatment was significantly better when treatment was initiated less than 6 weeks after the diagnosis of infantile spasms [10]. These results suggest the importance of early diagnosis and rapid treatment to improve long-term prognosis of Ibrutinib purchase infantile spasms in children with Down syndrome. This case study leads us to conclude that the initiation of Phenobarbital therapy is not the adequate treatment

for patients with Down syndrome associated with infantile spasms and psychomotor development delay. In the short-term, this treatment was effective immediately with a good clinical control of seizures. But in long-term, we observed an unfavorable progression with persistence of hypsarrhythmia Sclareol on EEG and severely impaired psychomotor development. The better knowledge about this association by physicians and parents would reduce the time to diagnosis and delay to treatment in order to optimize psychomotor development and improve the quality of life of these children. According to order. None declared. None declared. The work described in this article has been carried out in accordance with The Code of Ethics of the World Medical Association (Declaration of Helsinki) for experiments involving humans; EU Directive 2010/63/EU for animal experiments; Uniform Requirements for manuscripts submitted to Biomedical journals. “
“Koncepcja organizacyjna, rozwój i osiągnięty poziom naukowy poznańskiego uniwersyteckiego ośrodka pediatrycznego związany jest z osobą profesora Olecha Szczepskiego.