Patients included in controlled trials receive adequate inhaler training and have to demonstrate and maintain proper inhaler competence. Moreover, most randomized controlled trials are short-term trials and there is some evidence that, in the real world, inhaler technique deteriorates over time [31] and that may affect clinical outcomes [32, 33]. MK-4827 nmr Thus, results of real-world studies are warranted [16]. In this study we report the results of two multicentre, real-life studies with the use of the dry powder inhaler, Easyhaler®: one with twice-daily inhalations of formoterol in patients with asthma or COPD, and one with as-needed inhalations of salbutamol in children and adolescents with asthma. All

together, more than 1000 patients were included and they represent a wide age range, from 3 to 88 years of age. The studies were also of a sufficiently long duration—3 months and up to 1 year, respectively—in order to make reliable user evaluations possible. In the vast majority of the cases the investigators found Easyhaler® easy to teach, and second or third instructions were necessary in only 26 % of the patients. The https://www.selleckchem.com/products/cb-5083.html instruction to shake the inhaler appeared, for the patients, to be the most difficult manoeuvre to remember. After one instruction a total of 81 % of the children, 83 % of the adolescents,

87 % of the elderly and 92 % of the adults Repotrectinib performed all manoeuvres correctly. At the last study visit these figures had increased to a minimum of 93 %. The improved lung function values in all age groups, and both in asthma and COPD patients, also indicate that the inhaler competence remained good, as well as treatment adherence. It has been suggested that the ease Terminal deoxynucleotidyl transferase of use of an inhaler device may correlate with inhaler competence and thereby with adherence to treatment [14, 15]. The patients reported that it was easy to learn how to use Easyhaler® and they were satisfied or very satisfied with the use of the inhaler. The high figures for patient satisfaction and patients’ reports on how easy it was to learn the correct use of Easyhaler® may suggest

that this device is the most easy to use. That conclusion cannot, however, be drawn as no real comparison has been made. Our study also has other limitations. Most patients with airway diseases have used inhaler devices previously and have a good idea about inhalation manoeuvres in general. Therefore it would have been more reliable to expose patients not previously using inhalers (or volunteers) to the devices to be evaluated. The majority of patients whose previous inhaler devices were recorded had used a pMDI, which is the most difficult of all inhalers to use correctly [34, 35]. Almost one-fifth of the patients had used multiple devices. Therefore, it is not surprising that more than 50 % of both the asthma and COPD patients found Easyhaler® easier to use than their previous device. For the same reason, most patients reported that they were satisfied or very satisfied with Easyhaler®.