All data represent the mean ± SD of three independent experiments. *P < 0.05, **P < 0.01 vs. control (0 μg/ml). Conclusion: In summary, all available results demonstrate that HM effectively inhibits proliferation, induces apoptosis selleck chemical and inhibits migration and invasion of human gastric cancer cells in vitro and in vivo,
which provides a basis for developing it as a novel drug for human gastric cancer therapy. Key Word(s): 1. Harmine; 2. gastric cancer; 3. proliferation; 4. invasion; Presenting Author: CHEN GENG Additional Authors: XU HONG, WANG XIU, TAO KE, XIA YAN, HE CHUAN Corresponding Author: XU HONG Affiliations: The First Hospital of Jilin University Objective: To evaluate the efficiency and safety of endoscopic submucosal dissection PFT�� mw (ESD) with submucosal injection of sodium hyaluronate for gastric disease. Methods: 46 patients who were diagnosed gastric disease undewent ESD for total 48 times with submucosal injection of sodium hyaluronate from May, 2011 to April, 2013 (2 cases were given two operations because of the different parts of the lesions). Operation time was recorded, the total solution volume, en bloc resection rate and histological complete resection rate were calculated, postoperative complications and healing condition etc were observed.
Results: 46 patients with 48 lesions were removed successfully, including 6 cases of early carcinoma,27 cases of dysplasia, 5 cases of hyperplastic polyp, 1case of hemangioma, 1case of heterotopic pancreas, 1 case of carcinoid, 1case of inflammatory pseudotumor and 1case of ectopic gastric mucosa.the diameter of the lesion was 1.0∼7.0 cm with the mean of 2.20 ± 1.14 cm.The duration of operation from lesion mark to dissection surface dispose was 31 min∼179 min,and the average time was 69.27 ± 17.32 min. The mean dose of sodium hyaluronate for submucosal injection was 17.89 ± 7.49 ml,with the range of 5 ml∼35 ml. Basal or incisal edge was subject to lesion for histological diagnosis in 2 cases, and the complete resection rate was 95.8%. 1 case
was sutured by assist of laparoscope, 1 Urocanase case(2.01%) occurred delayed bleeding,no perforation happened. Average Length of Stay after ESD was 3.6 days(3∼5days).There were 11 cases with1,3 and 6 month follow-up by endoscopy, the surfaces of the dissection were completely cured, no recurrence and residual were found. Conclusion: Submucosal injection of sodium hyaluronate in ESD is a safe and effective procedure, which can provide complete histological specimen and significantly reduce the complication rate. Key Word(s): 1. sodium hyaluronate; 2. ESD; 3. safety; 4. efficiency; Presenting Author: HONGGANG YU Additional Authors: LINGLI ZHANG Corresponding Author: HONGGANG YU Affiliations: Renming Hospital Of Wuhan Univeristy; Renming Hospital of Wuhan University Objective: tumor suppressor gene phosphatase and tensin homolog (PTEN) is essential in inhibiting tumor growth and metastasis.