Antimicrob Agents Chemother 2005, 49:1782–1786.PubMedCrossRef 8. Cao L, Srikumar R, Poole K: MexAB-OprM hyperexpression in NalC-type multidrug-resistant Pseudomonas aeruginosa: identification and selleck screening library characterization of the nalC gene encoding a repressor of PA3720-PA3719. Mol Microbiol 2004, 53:1423–1436.PubMedCrossRef 9. Lee A, Mao W, Warren MS, Mistry A, Hoshino K, Okumura R, Ishida H, Lomovskaya O: Interplay
between efflux pumps may provide either additive or multiplicative effects on drug resistance. J Bacteriol 2000, 182:3142–3150.PubMedCrossRef 10. Quale J, Bratu S, Gupta J, Landman D: Interplay of efflux system, ampC, and oprD expression in carbapenem resistance of Pseudomonas aeruginosa clinical isolates. Antimicrob Agents Chemother 2006, 50:1633–1641.PubMedCrossRef 11. Tomas M, Doumith M, Warner M, Turton JF, Beceiro A, Bou G, Livermore LY333531 price DM, Woodford N: Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas
aeruginosa isolates from cystic fibrosis patients. Antimicrob Agents Chemother 2010, 54:2219–2224.PubMedCrossRef 12. Picao RC, Poirel L, Gales AC, Nordmann P: Diversity of beta-lactamases produced by ceftazidime-resistant Pseudomonas aeruginosa isolates causing bloodstream infections in Brazil. Antimicrob Agents Chemother 2009, 53:3908–3913.PubMedCrossRef 13. Andrade SS, Jones RN, Gales AC, Sader HS: Increasing prevalence of antimicrobial resistance among Pseudomonas either aeruginosa isolates in Latin American medical centres: 5 year report of the SENTRY Antimicrobial Surveillance Program (1997–2001). J Antimicrob Chemother 2003, 52:140–141.PubMedCrossRef
14. Marra AR, Pereira CA, Gales AC, Menezes LC, Cal RG, de Souza JM, Edmond MB, Faro C, Wey SB: Bloodstream infections with metallo-beta-lactamase-producing Pseudomonas aeruginosa: epidemiology, microbiology, and clinical outcomes. Antimicrob Agents Chemother 2006, 50:388–390.PubMedCrossRef 15. Gales AC, Menezes LC, Silbert S, Sader HS: Dissemination in distinct Brazilian regions of an epidemic carbapenem-resistant Pseudomonas aeruginosa producing SPM metallo-beta-lactamase. J Antimicrob Chemother 2003, 52:699–702.PubMedCrossRef 16. Li XZ, Nikaido H: Efflux-mediated drug resistance in bacteria: an update. Drugs 2009, 69:1555–1623.PubMedCrossRef 17. Vila J, Martinez JL: Clinical impact of the over-expression of efflux pump in nonfermentative Gram-negative bacilli, development of efflux pump inhibitors. Curr Drug Targets 2008, 9:797–807.PubMedCrossRef 18. Hocquet D, Muller A, Blanc K, Plesiat P, Talon D, Monnet DL, Bertrand X: Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of Pseudomonas aeruginosa. Antimicrob Agents Chemother 2008, 52:1173–1175.PubMedCrossRef 19.