Biomaterials produced from synthetic or biological polymeric hydrogels have discovered widespread applications in bio-medical engineering, ranging from tissue repair, regenerative medicine, to drug-delivery. These fat based hydrogels, nevertheless, still have several inherent disadvantages, such as for instance relatively slow degradation, unintended immune responses, and the creation of unwanted by products and services. 2 On another hand, supramolecular c-Met Inhibitors hydrogels,3 produced by low molecular weight gelators4 that self assemble in water through low covalent relationships, have attracted considerable attention because they show several unique merits, for example synthetic economy, bio-compatibility, low accumulation, inherent biodegradability, and, more importantly, fast thermally reversible formationdissociation functions. Among the molecules behave as the inspiration for supramolecular hydrogels, peptide based hydrogelators6 are normal candidates because of their biological significance, more successful synthetic chemistry,7 and the ability to create a large collection of various molecules from the small selection of residues. There are various samples of peptide based useful foundations in making nanofibers and generating hydrogels. The nano-fibers of peptide amphiphile Organism elements can exhibit a top density of epitopes for regulating the differentiation of neuron progenitor cells8 or driving cartilage regeneration. 9 A supramolecular hydrogel self constructed from lysinecontaining quick peptides reveals inherent antibacterial action. 10 Self supporting oligopeptides kind the hydrogels for cytokine release and cell culture. 11 Amino-acid functionalized when induced enzymatically hydrogel particles release protein. 12 A small peptide to conjugate with B lactam changes into a hydrogelator by the catalysis of the B lactamase. 13 A low molecular weight gelator containing amino acid moieties confers liquidcrystalline fits in. 14 Photo sensitive spiropyran linking with dipeptide leads LY2484595 to supramolecular hydrogel to answer both light and ligand receptor interaction. It’s necessary and important to discover new ways for producing supramolecular hydrogels as smart materials for controlled drug release in the particular sites or areas in a scientific process. Since colonic microflora produces azo reductase to lessen the azo group into the corresponding amine, olsalazine, being a prodrug and a substrate of azo reductase, achieves colon certain medicine delivery17 via catalytic generation of mesalazine inside the colon at the site of inflammation.