For example, current desensitizers include antibacterial components such as fluoride, triclosan, benzalkonium chloride, ethylene dianinetetraacetic acid, and glutaraldehyde. selleck chemicals KPT-330 A dentin primer incorporating methacryloyloxydodecylpyridinium bromide was potentially able to kill any bacteria.16,17 The agar well technique test is an accepted method for initially differentiating antibacterial activity between materials. Accordingly, even if the material contains less diffusive antibacterial components the substantive antibacterial activity is available. It is difficult to evaluate the antibacterial effects of desensitizer by a single test and more than one method needs to be used for screening the materials. Furthermore, in order to speculate on clinical effects, in situ tests which simulate the clinical situation are indispensable.
Dental plaque is a host-associated biofilm. In this study, some microorganisms of dental plaque were used to determine antibacterial effectiveness of several desensitizers. Mutans streptococci are found in highest numbers on teeth. These organisms have a strong affinity for hard surfaces, and do not usually appear in the mouth until after tooth eruption. S salivarious is only a minor component of dental plaque and not considered a significant opportunistic pathogen. However, S. salivarious and S. mutans have been found to produce root caries.18 S. fecalis have been recovered in low numbers from several oral sites. Some strains can include dental caries in gnotobiotic rats while others have been isolated from infected root canals and from periodontal pockets.
19 P. aeruginosa and S. aureus were colonized in pocket of the refractory chronic periodontitis patients.20 P. aeruginosa is resistant to tetracycline, penicillin G and erythromycin.19 Antibacterial effectiveness of the desensitizers except for UltraEZ and Cavity Sheath used in this study was obtained against the bacteria above. In a study by Emilson and Bergenholtz,21 it was suggested that the antibacterial nature of the Gluma and Denthesive cleanser might be related to the high content of ethylene dianinetetraacetic acid (EDTA) in the materials. The results of the present study also indicate that chemical composition of the desensitizers play an active role their antibacterial properties.
Micro Prime (MP) desensitizer is used for desensitizing Cilengitide under dental cements or temporary, provisional, or final restorative materials, abrasions, cervical erosions, and preps. The antibacterial activity of MP desensitizer may be related to the chemical composition, which is benzalkonium chloride in nature. MP desensitizer had significant inhibitory effect on not only S. Mutans and P. aeruginosa but also on S. salivarious, S. faecalis. and S. aureus. This data supports the results of Duran and Sengun,14 who reported antibacterial effect of benzalkonium chloride containing Heath-Dent desensitizer.