Herein, we evaluate if gender has an impact on outcomes after modern off-pump coronary artery bypass grafting (OPCAB). From 2002 to 2007, we analyzed
983 patients (male: n=807/female: n=176) who underwent OPCAB with symptomatic multi-vessel disease AG-881 at our institution. The link between gender and outcome was assessed by multivariate analysis and logistic regression. A composite endpoint was constructed from: 30-day-mortality, renal failure, prolonged intensive care unit (ICU) stay, neurological complications, use of intra-aortic balloon pump (IABP) and conversion to CPB. Mortality was 3.2% in women vs. 1.8% in men (P=0.15) and the EuroSCORE was significantly correlated to gender (6.8 vs. 5.2; P<0.001), even after correction (P=0.036). Significant more occurrence of the composite endpoint was noted in women (39.8% vs. 29.0%; P=0.007) whereas for men the risk was much lower [odds ratio (OR) 0.65; 95% confidence interval (CI) 0.46-0.92; P=0.015]. For both genders the logistic regression revealed a risk increase of
15% per one-point-increase of EuroSCORE (corrected) (OR 1.15; 95% CI: 1.10-1.19; P<0.0001). Women had more frequently a prolonged stay at ICU (P=0.006) and had a higher stroke rate (2.3% vs. 1.2%; P=0.29). Complete revascularization was achieved similarly (95% vs. 94%; P=0.93). OPCAB offers low mortality and excellent clinical outcome. buy BMS-777607 Women are more likely to experience postoperative complications. Even if partially neutralized by avoiding CPB, gender differences
remain present with modern OPCAB strategies. (C) 2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.”
“Objective. To investigate the associations of 25-(OH) D and beta-cell function or insulin resistance or albuminuria in Chinese type 2 diabetic patients. Methods. In total, 1408 type 2 diabetic patients without vitamin D supplement were included in this retrospective study. Results. Comparison between patients with and without 25-(OH) D deficiency indicated that, compared with patients with 25-(OH) D bigger than = 50 nmol/L, patients buy AICAR with 25-(OH) D smaller than 50 nmol/L showed a higher level of urine albumin-creatinine ratio (ACR) (90.15 +/- 10.30 mg/g versus 52.79 +/- 14.97mg/g). Multiple regression analysis indicated that 25-(OH) D was independently and negatively correlated with urine ACR (OR = 0.985, 95% CI 0.972-0.999, P = 0.03), adjusted by age, diabetic duration, HBP duration, SBP, HbA1c, creatinine, LDL-C, triglyceride, total cholesterol, and HDL-C. Compared with patients with normal level of urine ACR, patients with higher level of urine ACR showed a significant lower level of 25-(OH) D (34.49 +/- 13.52 nmol/L versus 37.46 +/- 13.6 nmol/L, P = 0.00).