However, MCIs and AD patients significantly differed

in layer II global volume only, despite a group effect in analysis of variance, while all the AD and NC values were significantly different. Global and neuronal atrophy were correlated with impairment of delayed and immediate recall.44 Quantified ERC β-amyloid (βA) load43 in MCIs was intermediate, but not significantly different from that found in NCs and AD patients respectively (again, NC vs AD values were significantly different), although analysis of variance revealed a significant group effect with a trend to find more linear increase from NCs to MCIs to AD patients. It is noteworthy that, some NC or MCI subjects had PA load equal to or higher than that seen in Inhibitors,research,lifescience,medical many AD patients, and two MCIs had no detectable βA. The inverse correlation Inhibitors,research,lifescience,medical between Mini-Mental State Examination (MMSFs)27 scores (mean scores: 27.3 in NCs and MCI patients, and 24 in AD patients) and βA load was not significant. In this study, 6 of 12 MCI subjects had a neuropathological diagnosis of possible AD according to the Inhibitors,research,lifescience,medical criteria of the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD).47 In a third study,45 neurofibrillary tangles (NFTs) and neuropil threads (NTs) were present in perirhinal cortex and ERC in

NCs, MCI subjects, and AD patients; the average number of NFTs increased with the diagnosis from NC to M’CI to AD. Retween-group differences analysis again found that MCI subjects were intermediate, but not significantly different from either NCs or AD patients. NFT density was inversely correlated with episodic memory score, but not with other, nonmemory, cognitive abilities across the three groups. Table III. Neuropathological Inhibitors,research,lifescience,medical characteristics of mild cognitive impairment in the Religious Order Study.43-45 CERAD, Consortium to Establish a Registry

for Alzheimer’s disease; MCI, mild Inhibitors,research,lifescience,medical cognitive impairment; NS, not significant; S, significant. Changes in MCI and … These studies first, show that no more than 50% of MCIs were incipient. AD. This is less than in the studies by Morris37, 40 and Price,41 and suggests that the populations described were not equivalent, although the use of different neuropathological diagnostic criteria makes the comparison difficult. Approximately the same proportion of NCs (45%) nearly were also diagnosed as possible AD; this finding suggests that the clinical diagnostic tools were neither sensitive nor specific in the detection of incipient AD. This can be explained by the fact, that both the NC and MCI groups had high and similar MMSE scores, but the concept of MCI precisely intends to detect cases missed by more global testing. Nevertheless, MCI subjects globally were, for most. F,RC lesions, intermediate between NC and AD cases. This suggests that ERC lesions could be a better neuropathological marker of MCI than the presence of those required for a diagnosis of AD.