It might be that some populations of patients have very little chance of benefiting from treatment, A situation of this type was identified in relation to the prevention of myocardial infarction (relapse rate) 3 years after a first infarction.12 Overall, propranolol had a protective effect of 3% (reinfarction rate of 12% with propranolol and 9% with placebo). But the relapse rate was 6% in subjects with a high educational level compared to 13%; when this level was low, and 2%) in subjects with low stress and social isolation compared to 14% when these were high. These findings in the field of

cardiology suggest that financial, Inhibitors,research,lifescience,medical social, or educational measures might be more effective than drug treatment in disadvantaged patients groups. How this concept applies Inhibitors,research,lifescience,medical to AD treatment is still unclear. It is possible that the risk of developing psychiatric adverse drug reactions is dependent on the patients more than the drugs themselves. For example, hyperthymic personality might be an independent risk factor for drug-induced hypornania. The Inhibitors,research,lifescience,medical rule of baseline characteristics states that if a patient presents with a preexisting physical

abnormality before treatment, then the risk of an iatrogenic reaction having the characteristics of this abnormality is greatly increased. Thus, an elderly patient with age-related cognitive decline will be more sensitive to die amnestic effects of anticholinergics Inhibitors,research,lifescience,medical or benzodiazepines, and a patient with orthostatic hypotension will be more sensitive to the hypotensive effects of medications. With ADs, the rule of baseline characteristics is probably predictive of a greater risk for most adverse drug reactions. Interindividual differences are the domain of phannacogenetic studies, and the hope is that better knowledge of genetic polymorphism will facilitate the prediction of both the favorable Inhibitors,research,lifescience,medical and adverse effects of drugs. Cost of antidepressant therapy Health care costs have long been a cause for concern and, indeed, there is no room for euphoria when health

care costs are soaring to more than 10% Histone demethylase of gross national products in some Western countries. In 1978, the Palo Alto Times published a cartoon in which Cicero was playing die part of a doctor being asked by Bugs Bunny: “How sick am I doc?” Cicero’s answer was: ‘That depends on how well you are insured.“ Health economists have conflicting interests; each individual, each institution wishes to maximize its benefits and minimize its losses, with little consideration for the health and well-being of the nation as a whole. In Switzerland, a Sotrastaurin molecular weight well-known insurance company gave a regrettable confirmation of this sad state of affairs when they stopped providing the basic mandatory insurance package in Swiss cantons where health expenditure was judged to be too high. The American public holds the belief that ”managed care has killed patient care.