Nonetheless, the negative-predictive value is high [35]. Therefore, re-biopsy of residual FDG-avid lesions post-therapy should always be considered. Those with persistent disease should be considered for salvage therapy, and those who have achieved a CR, observed. The decision to offer consolidation radiotherapy should be made at presentation (i.e., to bulk disease or bony lesions) and not to residual FDG-avid lesions in those treated with curative intent, as PET-positive lesions may represent more widespread disease. RT may be offered to those with PET-positive lesion(s) and who are ineligible for salvage buy BGJ398 chemotherapy. There are scant data regarding long-term follow-up of survivors of lymphoma treatment

in the HIV setting. However, it is well described in the HIV-negative setting that prior anthracyclines (e.g., doxorubicin) are associated with cardiomyopathy and heart failure. Although it is unclear PI3K Inhibitor Library if the incidence is higher in the HIV setting, patients with other cardiovascular risk factors (e.g., blood pressure, lipids, family history) may deserve greater surveillance. Chemotherapy for lymphoma is associated with an increased risk of myelodysplasia and acute myeloid leukaemia arising some 2–7 years later, often with cytogenetic abnormalities of chromosomes 5, 7 or 12. Chemotherapy

is also associated with an increased risk of second solid tumours, although previous radiotherapy is the greater risk factor. Other potential issues include endocrine and metabolic complications. Follow-up varies between centres but generally patients with aggressive histologies are seen every 3 months in the first year, 4–6 monthly for the second and third and thereafter 6 monthly until 5 years post treatment.

Patients are then often discharged to 6-phosphogluconolactonase primary care (having received an ‘end-of-treatment summary’) although data regarding long-term side effects in patients with HIV who have received treatment for lymphoma are scant. In light of this some patients continue to be monitored on an annual basis. 1 Beral V, Peterman T, Berkelman R, Jaffe H. AIDS-associated non-Hodgkin lymphoma. Lancet 1991; 337: 805–809. 2 Biggar RJ, Rosenberg PS, Cote T. Kaposi’s sarcoma and non-Hodgkin’s lymphoma following the diagnosis of AIDS. Multistate AIDS/Cancer Match Study Group. Int J Cancer 1996; 68: 754–758. 3 Cote TR, Biggar RJ, Rosenberg PS et al. Non-Hodgkin’s lymphoma among people with AIDS: incidence, presentation and public health burden. AIDS/Cancer Study Group. Int J Cancer 1997; 73: 645–650. 4 Engels EA, Biggar RJ, Hall HI et al. Cancer risk in people infected with human immunodeficiency virus in the United States. Int J Cancer 2008; 123: 187–194. 5 Highly active antiretroviral therapy and incidence of cancer in human immunodeficiency virus-infected adults. J Natl Cancer Inst 2000; 92: 1823–1830. 6 Stebbing J, Gazzard B, Mandalia S et al.