Preliminary results (not shown) suggested that transfected tumor cells have an increased in vitro adhesion and proliferation in a similar manner as mucin or NeuGc-treated cells. SB202190 clinical trial Since NeuGc-GM3 is a postulated tumor antigen in human cancers [39], development of NeuGc-positive murine tumor cells allows the click here possibility to evaluate cancer vaccines in animal models [40]. Considering the results obtained we hypothesize that NeuGc presence in the cell membrane is actively involved in the early phases of tumor formation and takes part
in tumor nesting at distant sites. Acknowledgements We would like to thank Juan Garona for technical support. MRG, DEG and DFA are members of the National Council for Scientific and Technical Research (CONICET, Argentina). The study was supported by grants from the National Agency of Scientific and Technological Promotion, Quilmes National University and Elea Laboratories (Argentina). References 1. Kannagi R, Chang Gung Med J: ABT-737 datasheet Carbohydrate antigen sialyl Lewis a–its pathophysiological significance and induction mechanism in cancer progression. Chang Gung Med J 2007, 30: 189–209.PubMed 2. Patra
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