Results: The female patients reported significantly lower psychological dimension of QOL than their male counterparts (p = 0.009). Also for the females, a negative correlation was found between pain intensity and QOL (r = -0.504, p <0.0001), as well as positive correlations between pain intensity and fatigue (r = 0.421, p <0.0001) and depression (r = 0.368, Batimastat in vitro p <0.0001).
Stepwise linear regression analyses showed that among the females, QOL was significantly predicted by pain intensity as well as by depression (F-(2,F-75)= 52.62, p < 0.0001, Adj. R-2= 0.57). However, among the males, depression was the only symptom found to predict QOL (F-(2,F-30)= 9.72, p < 0.001, Adj. R-2= 0.39).
Conclusion: Therefore, it is concluded
that gender should be considered as an additional feature for further characterizing QOL. Gender differences in factors predicting QOL warrant different clinical approaches to male and female patients, and identifying these differences may assist health care providers in tailoring treatment modalities to individual patients for optimal outcomes. (C) 2011 Elsevier Ltd. All rights reserved.”
“Novel amphiphilic, thermo- and pH-responsive polyaspartamides showing both double-responsive (pH and temperature) behavior and a sol-gel Nutlin-3 inhibitor transition were prepared and characterized. The polyaspartamide derivatives were synthesized by the successive aminolysis reactions of polysuccinimide using both hydrophobic N-alkylamine (laurylamine, octylamine, hexylamine) and hydrophilic N-isopropylethylenediamine. The composition of each component was analyzed
Selinexor cost by (1)H NMR. At the intermediate composition range, the system showed a lower critical solution temperature behavior in water. The transition temperature (pH dependent) could be modulated by changing the alkyl chain length and graft composition. The temperature dependence of the nanoparticle size distribution of the polyaspartamide derivatives was also examined. The critical micelle concentration of the copolymers in a phosphate-buffered saline (pH 7.4) solution ranged from 6 to 20 mu g/L. In addition, physical gelation, i.e., a sol-gel transition, was observed in a concentrated solution. These novel double-responsive and injectable hydrogels have potential biomedical applications such as drug delivery systems and tissue engineering. (C) 2008 Wiley Periodicals, Inc. J Appl Polym Sci 111: 998-1004, 2009″
“Study Design. Whole ovine caudal intervertebral discs (IVD) were cultured in sufficient and limited nutrition under simulated-physiologic loading for 7 and 21 days.
Objective. To study the effect of limited nutrition on disc cells embedded in their native tissue in short-and midterm whole organ disc culture.
Summary of Background Data.