Spectroscopic evidence showed that vitamin C and aspirin bind BSA via hydrophilic interactions

(polypeptide and amine polar groups) with overall binding constants of K(vitamin) (C-BSA) = 1.57 x 10(4) M(-1) and K(aspirin-BSA) = 1.15 x 10(4) M(-1); assuming that there is one drug molecule per protein. The BSA secondary structure was altered with major decrease of alpha-helix from 64% (free protein) to 57% (BSA-vitamin C) and 54% (BSA-aspirin) and beta-sheet from 15% (free protein) to 6-7% upon drug complexation, inducing a partial protein destabilization. (C) 2011 Elsevier B.V. All rights reserved.”
“Background. Chronic pancreatitis (CP) is defined as a continuing inflammatory disease of the pancreas characterised by irreversible morphological changes, often associated with pain and with the loss of exocrine and/or endocrine function that may be clinically relevant. Alcohol is the CCI-779 in vitro predominant cause of CP in the western world and is particularly prevalent in South Africa, especially in the indigent patient. CP ranks high among intractable diseases of the gastrointestinal tract. The tendency for substance abuse in the alcohol-induced group poses major psychological and socioeconomic problems.\n\nObjective. CP is a disease with significant clinical and pathological

heterogeneity. Level 1 evidence to support definitive guidelines for diagnosis, medical management and interventional therapy is lacking. Despite this paucity of robust scientific evidence, it Alvocidib in vivo is important to provide some assistance based on the best available evidence as to the current standard of care for CP the South African context; this will aid all involved in the management of the disease, and includes clinicians, health care managers and funders.\n\nScope. The guidelines were developed as recommendations addressing selleck chemical the diagnosis, medical management and interventions, both endoscopic and surgical, for the management of a very complex and heterogeneous disease of the pancreas. The recommendations are particularly

relevant in the South African context where the predominant patho-aetiological agents are alcohol-associated with smoking.\n\nRecommendations. The guidelines provide clear recommendations regarding the diagnostic modalities available, both imaging (which includes MRI and endoscopic ultrasound (EUS)) and pancreatic function tests. The section on medical management makes recommendations on the use of analgesics, enzyme replacement and other therapeutic options in the non-interventional management of the majority of patients with CP. The section on interventional procedures identifies the indications and options available for the interventional management of both uncomplicated and complicated CP.