The Shariati hospital is one of the large referral centers in Iran with 220438 admissions that 7000 admissions (3.17%) were in DD service in this period. Results: The overall hospital mortality

in this period was 6172, which 450 (7.2%) of them were in DD service. The mortality in DD service was BMN 673 price 7.29%. 68.44% of death was in men (age 58.05 ± 16.42) and 31.55% was in women (age 55.65 ± 18.68). LC was the most common causes of death in DD service (53.6%). Another important causes of mortality in this service were cholangiocarcinoma (14.76%), non- variceal upper GI bleeding (13.80%), cancer of pancreas (10.47%), and gastric cancer (9.53%). The most common etiological diagnoses in cirrhosis group were hepatitis B virus (39.16%), cryptogenic cirrhosis (29.58%), hepatitis C virus (10.41%), autoimmune hepatitis (9.05%), cholestasis disease (7.25%), and Wilson disease (4.16%). The most common presentations of patients who died were hepatic encephalopathy (52.0%), hepatorenal syndrome (22.1%), variceal bleeding (20.04%), and spontaneous bacterial peritonitis

(3.06%). Conclusion: The http://www.selleckchem.com/products/ink128.html hospital mortality in DD service was higher than the overall hospital mortality. Cirrhosis of liver is the most common and the GC is the fifth causes of death in patients who have been admitted in DD service. In addition to HBV vaccination, appropriate preventive measures and transplant facilities needs to lower this burden. Key Word(s): 1. Chronic liver ; 2. Hospital mortality; 3. Cirrhosis; 4. Iran; Presenting Author: GUOZUN ZHANG Additional Authors: XIAOLAN ZHANG Corresponding Author: XIAOLAN ZHANG Affiliations: The Second Hospital of Hebei Medical University Objective: Background: Cirrhosis is a long-term consequence of chronic hepatic injury and no effective therapy is currently available for this disease. Mesenchymal stem cells (MSCs) can differentiate into hepatocytes in vitro. Moreover, MSCs have the capacity

to alleviate liver fibrosis. The aim of this study was to investigate whether human umbilical cord-derived MSCs (hUC-MSCs) could differentiate into find more hepatocyte-like cells in fibrotic and cirrhotic rat model and its differentiation mechanism. Methods: Wistar rats received hypodermic injection of 2 mL/kg CCl4 dissolved in olive oil (2:3) twice a week to induce the liver fibrosis and cirrhosis model. After the model was successful, hUC-MSCs were injected into the rats via tail vein, saline as the control. 120 wistar rats were randomly divided into following groups: control group(CCl4/saline 0 wk, n = 8), model group (Liver fibrosis model group: CCl4/saline 4 wks, 5 wks, 7 wks; liver cirrhosis model group: CCl4/saline 8 wks, 10 wks, 14 wks, n = 8), MSCs transplantation group (liver fibrosis MSCs transplantation group: CCl4/MSCs 0 wk, 1 wk, 2 wks, 4 wks; liver cirrhosis MSCs transplantation group: CCl4/MSCs 0 wk, 2 wks, 4 wks, 8 wks, n = 8).