“
“Warm ambient temperature facilitates hyperthermia and other neurotoxic

responses elicited by psychogenic drugs such as MDMA and methamphetamine. However, little is known about the neural mechanism underlying such effects. In the present study, we tested the hypothesis that a warm ambient temperature may enhance the responsivity of 5-HT2A receptors in the central nervous system and thereafter cause an augmented response to 5-HT2A receptor agonists. This hypothesis was tested by measuring changes in body-core temperature in response to the 5-HT2A receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) administered at four different ambient temperature selleck chemical levels: 12 degrees C (cold), 22 degrees C (standard), 27 degrees C (thermoneutral zone) and 32 degrees C (warm). It was found Selleck GDC 973 that DOI only evoked a small increase in body-core temperature at the standard (22 degrees C) or thermoneutral ambient temperature

(27 degrees C). In contrast, there was a large increase in body-core temperature when the experiments were conducted at the warmer ambient temperature (32 degrees C). Interestingly, the effect of DOI at the cold ambient temperature of 12 degrees C was significantly reduced. Moreover, the ambient temperature-dependent response to DOI was completely blocked by pretreatment with the 5-HT2A receptor antagonist ketanserin. Taken together, these findings support the hypothesis that 5-HT2A receptors may be responsible for some neurotoxic effects of psychogenic drugs in the central nervous system, the activity of which is functionally inhibited at cold but enhanced at warm ambient temperature in contrast to that at standard experimental conditions. Published by Elsevier Ireland Ltd.”
“The evaluation of response to radiotherapy in patients with laryngeal cancer is a challenge because of the difficulty to differentiate between post-therapy changes and recurrent or residual tumor. Positron emission tomography is a non-invasive imaging tool that may be helpful in this differentiation. In this study, [F-18]-fluoro-3′-deoxy-L-thymidine

buy MK5108 ([F-18]FLT), a proliferation tracer is compared with 2-[F-18]-fluoro-2-deoxy-D-glucose ([F-18]FDG).\n\nPatients with primary laryngeal cancer, scheduled to undergo radiotherapy were included in this study. Patients underwent both [F-18]FLT-PET and [F-18]FDG-PET shortly before radiotherapy. Ten patients underwent [F-18]FLT-PET and [F-18]FDG-PET 2-3 months after radiotherapy. Scans were analyzed visually for areas of increased tracer uptake. The standardized uptake value (SUV) was measured as a semi-quantitative value of tracer uptake.\n\nFourteen patients, all male, were included in this study. Both [F-18]FLT-PET and [F-18]FDG-PET showed increased tracer uptake in 12 out of 14 patients (86%). [F-18]FDG uptake was significantly higher than [F-18]FLT uptake (SUVmax: 4.5 vs. 2.4 (P = 0.