1,2 The preeclampsia syndrome, clinical trial either alone or superimposed on the chronic hypertension, is the most serious hypertensive disorder in pregnancy. Preeclampsia is defined as the development of hypertension or proteinuria, or both after week 20 in a woman with previously
normal blood pressure.3 Proteinuria is a defining dysfunction of preeclampsia. The degree of proteinuria may fluctuate widely over any 24-hour period due to the circadian Inhibitors,research,lifescience,medical variation of urinary albumin excretion.4,5 It is also influenced by several factors including contamination, urine specific gravity, pH, exercise and posture.6 However, Douma et al showed that, in comparison with the non-pregnant Inhibitors,research,lifescience,medical controls, there was smaller or even absence of circadian variation during pregnancy. Quantification of a timed collection of urine protein has been the gold standard for many decades, and is expressed as the amount of protein excreted in the urine per unit of time. Twenty four-hour specimens have been used on a routine
basis.4,5 The 24-hour period required for the collection of urine may result in a delay in the diagnosis and treatment, or possibly the prolongation of hospital stay. Shortening the period required for the diagnosis of preeclampsia would be valuable Inhibitors,research,lifescience,medical for management purposes as well as for decreasing hospital cost and patient inconvenience.7,8 Several investigators have reported more rapid methods of identifying proteinuria such as the use of protein to creatinine ratios and dipsticks for protein in random urine specimens.7-9 The aim of this study was to determine Inhibitors,research,lifescience,medical whether 4-hour urine protein values correlate with those of 24-hour values in women with hypertensive disorders in pregnancy. Materials and Methods The study Inhibitors,research,lifescience,medical was
performed from October 2007 to July 2008 recruiting pregnant women referring to Kosar Obstetrics Hospital, Urmia University of Medical Sciences. All hypertensive patients with a blood pressure (BP) of ≥140/90 mmHg and a positive proteinuria (at least 1+) who were pregnant for more than 20 weeks and had provided a 24-hour urine samples for urinary protein, as requested by their physicians to rule out preeclampsia, were included in the study. Proteinuria was defined as Annual Reviews a 24-hour urinary protein excretion of more than 300 mg, a urine protein to creatinine ratio of ≥0.3 or persistent proteinuria (30 mg/dl, 1+ dipstick ) in random urine samples. Patients with gestational hypertension have only <300 mg, those with mild preeclampsia have 300 mg to 2000 mg, and those with severe preeclampsia have >2000 mg of protein in their 24-hour urine samples.5 The University Ethics Committee approved that patients’ consent were not required for their participation. Patients were excluded from the study only if they did not complete the 24-hours of collection because of delivery.