Flicker et al17 followed 32 normal (GDS=l-2) and 32 MCI cases (GDS=3) over a 2-year follow-up interval and found that 72% of the mildly impaired group progressed to a dementia diagnosis.

Classification analyses of the four cognitive tests that showed poorer scores at baseline among the decliners yielded high levels of specificity and sensitivity These four tests assessed verbal Inhibitors,research,lifescience,medical recall, visuospatial recall, and two aspects of language function. The verbal recall test (learning a shopping list) was the best single predictor, correctly classifying 95% of the nondecliners and 90% of the decliners. Kluger et al48 studied 213 nondemented elderly (GDS=l-3) over an average Inhibitors,research,lifescience,medical follow-up interval of 3.8 years. Of the 87 MCI (GDS=3) cases followed, 68% declined to dementia. Cut-scores from a paragraph delayed recall test assessing recent memory correctly identified 92% of the decliners and 79% of the nondecliners, yielding an overall predictive accuracy of 87%. A diagnostically more restrictive subset of this MCI sample (N=71) was also examined, of whom 66% declined to a diagnosis of probable AD. This same paragraph cutscore correctly identified 96% of the decliners and 83% of the nondecliners, providing an overall accuracy of 92%. Similar

findings have been reported by Tierney et al41 Inhibitors,research,lifescience,medical for a cognitively diverse sample of research clinic-based, nondemented elderly individuals Inhibitors,research,lifescience,medical (GDS=2-3), by Devanand et al38 for individuals with scores of CDR=0 to 0.5, as well as by Masur et al28 for nondemented, healthy communityresiding elderly, who are likely to be comprised of

both normal and MCI individuals. An overview of relatively largesample longitudinal studies (N>70) that have reported predictive accuracies of either individual or small sets of baseline neuropsycho logical test scores for predicting Epigenetic inhibitor price subsequent decline to dementia is provided in Table II.28,38,41,44,48,59,61,62 These studies Inhibitors,research,lifescience,medical are organized according to the PRT062607 cost composition of the nondemented samples at baseline: (i) primarily normal/AAMI/ARCD elderly; (ii) various combinations of normal and MCI cases; or (iii) only MCI cases. One general pattern that emerges from this organizational scheme is “the greater the proportion of MCI cases in the nondemented sample, the greater the subsequent rates of decline.” The reported predictive accuracies include specificity versus sensitivity and/or negative predictive value versus positive predictive value. The specificity of a test signifies the percentage of all truly nondeclining cases accurately classified by the predictor variable, while the sensitivity indicates the percentage of all truly déclining cases accurately classified by the predictor variable.