Current psychological treatments have been only partially successful, and so developing more robust treatment applications to address this multi-faceted problem are warranted (Kearney, 2008; King & Bernstein, 2001; King et al., 2000). Findings from a large community sample of 9- Ponatinib nmr to 16-year-olds place three-month prevalence rates of anxiety-based SR and truancy at 8% (Egger et al., 2003). However, the picture complicates when broader definitions are included. National data have estimated that 20% of fourth- and eighth-graders have missed three days of school or more in the past month and 7% have missed

five days or more (National Center for Education Statistics, 2006). The short- and long-term effects of SR behavior are dramatic and include poor academic performance, social alienation, family conflict, and potential child maltreatment from lack of supervision (Last & Straus, 1990; Kearney & Albano, 2007; King & Bernstein, 2001; King et al., 2000). Continued absenteeism brings legal troubles, financial distress, and increased rates of high-risk behaviors (e.g., alcohol/drug use, perilous sexual NVP-BEZ235 ic50 behavior), and ultimately can be associated with poor long-term occupational and social functioning (Kearney, 2008; King & Bernstein, 2001). Moreover, SR can be a costly burden to the education system in terms of professional time (guidance counselors,

teachers, principals, social workers, etc.), as well as the expense of alternative schools for children who are terminated from the public school system for SR behavior. To address these needs, cognitive behavioral interventions have been examined and received modest empirical support. One test of cognitive behavioral therapy (CBT; King et al., 1998), consisting of four Resveratrol weeks of individual CBT (6 sessions) plus parent and teacher training (5 sessions) resulted in 88% of youth returning to normal attendance (90% of days), compared to 29% of youth in a no-treatment waitlist. Other trials have demonstrated more modest outcomes. Last, Hansen, and Franco (1998)

compared individual CBT versus an attention placebo control, and results suggested that CBT may not be sufficient to produce change beyond education and support. Twelve weeks of CBT based on adult agoraphobia treatment resulted in 67% average attendance rates by posttreatment, and 65% of youth achieved 95% attendance, but these results were nonsignficantly different from the attention control. Notably, 27% of the participants dropped out of this study due to families seeking more treatment than was offered, refusing the offered treatment, or being terminated for excessive session cancellations. Similar results were found in a comparison of combined CBT plus tricyclic medication compared to CBT plus pill placebo (Bernstein et al., 2000).