The two-sample t test was used to test for differences between the groups indicated. Statistical significance was determined Trichostatin A solubility dmso based on a P value ≤ 0.05. All experiments were repeated a minimum of three times to ensure reproducibility. Acknowledgements and Funding This work was supported
by the National Science Council and China medical University of Taiwan R.O.C. (NSC98-2320-B-040-013- to Yi-Chyi Lai, NSC92-2314-B-039-008- to Min-Chi Lu and CMU-95-109 to Chingju Lin). Electronic supplementary material Additional file 1: Induction of diabetic mice. The file contains supplemental figure S1 that presents the successful induction of diabetic mice in this study. (PDF 155 KB) References 1. Podschun R, Ullmann U: Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev 1998, 11 (4) : 589–603.PubMed 2. Wang JH, Liu YC, Lee SS, Yen MY, Chen YS, Wang JH, Wann SR, Lin HH: Primary liver abscess due to Klebsiella pneumoniae in Taiwan. Clin Infect Dis 1998, 26 (6) : 1434–1438.PubMedCrossRef 3. National Nosocomial Infections Surveillance (NNIS) Selonsertib supplier report, data summary from Selleckchem LCZ696 October 1986-April 1996, issued May 1996. A report from the National Nosocomial Infections Surveillance (NNIS) System Am J Infect Control 1996, 24 (5) : 380–388. 4.
National Nosocomial Infections Surveillance (NNIS) report, data summary from October 1986-April 1997, issued May 1997. A report from the NNIS System Am J Infect Control 1997, 25 (6) : 477–487. 5. Lee KH, Hui KP, Tan WC, Lim TK: Severe community-acquired pneumonia in Singapore. Singapore Med J 1996, 37 (4) : 374–377.PubMed 6. Feldman C, Ross S, Mahomed AG, Omar J, Smith C:
The aetiology of severe community-acquired pneumonia and its impact on initial, empiric, antimicrobial chemotherapy. Respir Med 1995, 89 (3) : 187–192.PubMedCrossRef 7. Chen CW, Jong GM, Shiau JJ, Hsiue TR, Chang HY, Chuang YC, Chen CR: Adult bacteremic pneumonia: bacteriology and prognostic factors. J Formos Med Assoc 1992, 91 (8) : 754–759.PubMed 8. Cheng DL, Liu YC, Yen MY, Liu next CY, Shi FW, Wang LS: Pyogenic liver abscess: clinical manifestations and value of percutaneous catheter drainage treatment. J Formos Med Assoc 1990, 89 (7) : 571–576.PubMed 9. Fung CP, Chang FY, Lee SC, Hu BS, Kuo BI, Liu CY, Ho M, Siu LK: A global emerging disease of Klebsiella pneumoniae liver abscess: is serotype K1 an important factor for complicated endophthalmitis? Gut 2002, 50 (3) : 420–424.PubMedCrossRef 10. Yang CC, Yen CH, Ho MW, Wang JH: Comparison of pyogenic liver abscess caused by non-Klebsiella pneumoniae and Klebsiella pneumoniae. J Microbiol Immunol Infect 2004, 37 (3) : 176–184.PubMed 11. Wild S, Roglic G, Green A, Sicree R, King H: Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004, 27 (5) : 1047–1053.PubMedCrossRef 12. Pozzilli P, Leslie RD: Infections and diabetes: mechanisms and prospects for prevention.