Oxygen deficiency in LSMO would be the main source of these traps. Besides, a low density of sub-nano voids of similar to 6 angstrom was found in the substrate and in the thin LSMO/STO films. (C) 2011 American Institute of Physics. [doi:10.1063/1.3631825]“
“Chronic myeloid leukemia (CML) is infrequent in children. The best-known treatment is stem cell transplant. In a country with
limited resources like Sudan, such expensive therapy is not available. Torin 1 solubility dmso Alternative approaches are needed to help these children. The tyrosine kinase inhibiter–imatinib–might be an answer to this problem. The objective of this study is to determine the pattern of children with CML, their hematological response to imatinib, and tolerance and side effects to this drug. All patients with confirmed BCR-ABL by polymerase chain reaction (PCR) were included in this study. The relevant data were collected and the patients were started on imatinib.
Response to treatment was assessed clinically and hematologicaly only. Cytogentics and molecular studies are not available. The average age of the 31 patient evaluated was 8.7 years, 2 patients were less than 1 year, and 5 patients, ie, 16%%, were 2 years old or less. Chloroma was observed in 6 (19%%) patients. The average of the white blood cell (WBC) count was 206.6 xx 10<SU9</SU/L and the platelet count average was 523 xx 10<SU9</SU/L. Fer-1 datasheet Two (6.5%%) of the 31 patients presented as acute myeloid leukemia (AML). All patients had hematological remission within 2 months. Twenty-three (74%%) had a sustained remission over an average follow-up period of 26 months (2–67 months). Six (19%%) patients died with AML or sepsis.
Side effects to imatinib were infrequent, observed in 4 out of 29 (13.7%%) selleck inhibitor patients, and mild. One patient only needed dose modification. No resistance was observed during this period. CML patients present at an earlier age than in other parts of the world. Imatinib is safe and effective in treating pediatric CML where stem cell transplant in not available. Further cytogentics are important to monitor response and proper management.</.”
“Background: Atrophy-hypertrophy complex (AHC) of the liver rarely complicates post-cholecystectomy benign biliary strictures (BBS). This study aimed to analyse the effect of AHC on the surgical management of patients with BBS.
Methods: Between 1989 and 2005, 362 patients underwent surgical repair for BBS at a tertiary referral centre in northern India. A total of 36 (10%) patients had AHC. Patients with AHC (n = 36) were compared with those without (n = 336) to define the factors associated with the development of AHC.
Results: Overall, 35 patients with AHC underwent Roux-en-Y hepaticojejunostomy; right hepatectomy was performed in one patient. The interval between bile duct injury and stricture repair did not influence the development of AHC (mean 24 months in AHC patients vs. 19 months in non-AHC patients; P = 0.