Results-No significant differences were detected among sedation treatments for head height, response to noise, or response to arthrocenteses. Insertion of a dental float was easiest with treatment XBK2 and most difficult with treatments XK1 and XK2. Response to a needle prick on the flank was lowest with treatment XB and highest with treatment XK2. Tolerance to algometer pressure over CFTR inhibitor the scapula was highest with treatment XBK2 and lowest with treatment X.

Conclusions and Clinical Relevance-Administration of a subanesthetic dosage of ketamine with xylazine and butorphanol may facilitate certain procedures, such as insertion of a dental

float, in horses and enhance tolerance to pressure stimulation, but it may worsen responses to acute pain, such as that caused by a needle prick. Further evaluation is needed to determine whether subanesthetic dosages of ketamine might be useful when performing certain clinical procedures in horses. (J Am Vet Med Assoc 2011238:1629-1633)”
“The melt-spun Fe83.3-84.3Si4B8P3-4Cu0.7 alloys have a heterogeneous amorphous structure including a large amount of alpha-Fe-like clusters. Compared with the FeSiB alloys, the particle

size rapidly decreases from several hundred nanometers to 2-3 nm due to the proper amounts of simultaneous P and Cu additions. By controlling the crystallization process, a homogeneous nanocrystalline MEK inhibitor side effects structure composed by small alpha-Fe grains with size of 10-17 nm in diameter can be realized from the heterogeneous amorphous alloys. The nanocrystallized Fe83.3-84.3Si4B8P3-4Cu0.7 alloys show the extremely high saturation magnetic flux density of 1.88-1.94 T sufficiently near to 1.97 T of Fe-3.5 mass % Si crystalline soft magnetic alloys, and exhibit low coercivity of less than 10 A/m and higher effective BKM120 clinical trial permeability of 16 000-25 000 at 1 kHz due to the simultaneous realization of the homogeneous nanocrystalline structure and the small magnetostriction of (2-3) X 10(-6). In addition, the nanocrystalline alloys exhibit the superior core loss to the representative Fe78Si9B13 amorphous alloy at 50 Hz. (C)

2009 American Institute of Physics. [DOI: 10.1063/1.3058624]“
“A community of acidochemolithotrophic microorganisms with a high oxidation rate of pyrrhotite-containing sulphide ore flotation concentrate was selected. The Acidithiobacillus caldus OP-1 and Ferroplasma acidiphilum OP-2 cultures were identified to be dominating members. The presence of the Acidithiobacillus ferrooxidans OP-3, Leptospirillum ferriphilum OP-4, and Sulfobacillus thermosulfidooxidans OP-5 cultures in the community’s composition was also mentioned. The analysis results of solid residues of the process showed a greater elemental sulfur oxidation level and gold recovery when the initial pH value in tank I was maintained at a level of 1.8-2.0 (90.5%) rather than 1.6-1.8 (86.3%).

2% +/- 5.4% and 58.1 +/- 7.1%, respectively. With the quadrant method, anteromedial and posterolateral tunnels were measured at 21.7% +/- 2.5% and 35.1% +/- 3.5%, respectively, from the proximal condylar surface (parallel to the Blumensaat line), and at 33.2% +/- 5.6% and 55.3% +/- 5.3% from the notch roof (perpendicular to the Blumensaat line). Intraobserver and interobserver reliability was high, with small standard errors of measurement.

Conclusions: This cadaver study provides reference data against which tunnel position in anterior cruciate

ligament reconstruction can be compared in future clinical trials.”
“Advances in human genome sequencing and generation of public Panobinostat manufacturer databases of genomic diversity enable nephrologists to re-examine the genetics of common, complex kidney diseases. Non-diabetic kidney diseases CA3 prevalent in African ancestry populations and the allelic variation described in chromosome 22q12.3 is one such illustrative example. Newly available genomic database information enabled research groups to discover common functional DNA sequence risk variants in the APOL1 gene. These variants (termed G1 and G2) evolved to confer protection from a species of trypanosomal infection and thus achieved high prominence in many geographic regions of Africa and have been carried

over to African diaspora communities worldwide. Since these discoveries two years ago, new insights have been gained: localization of APOL1 in normal and disease kidney tissues; influence of the APOL1 variants on the histopathology of HIV kidney disease; possible association with kidney transplant durability; onset of kidney failure at a younger age; association with blood lipid concentrations; more precise geographic localization of individuals

with these variants to western and southern African ancestry; and the absence of the variants and kidney disease predisposition in Ethiopians. The definition of APOL1 nephropathy also confirms the long-held assumption by many clinicians that kidney disease attributed to hypertension in African populations https://www.sellecn.cn/products/nvp-bsk805.html represents an underlying glomerulopathy. Still awaited is the delineation of the biologic mechanisms of cellular injury related to these variants, to provide biologic proof of the APOL1 association and to provide potential targets for preventive and therapeutic intervention.”
“Background: Transtibial drilling techniques are widely used for arthroscopic reconstruction of the anterior cruciate ligament, most likely because they simplify femoral tunnel placement and reduce surgical time. Recently, however, there has been concern that this technique results in nonanatomically positioned bone tunnels, which may cause abnormal knee function.

6%), in SD male (29.8%), and in SD female (55.0%) neonates. TM exposure also resulted in a significant increase in cerebellar levels of the oxidative stress marker 3-nitrotyrosine in SHR female (35.1%) and SD male (14.0%) neonates. The activity of cerebellar type 2 deiodinase, responsible for local intra-brain conversion of thyroxine

to the active hormone, 3′,3,5-triiodothyronine (T3), was significantly decreased in TM-exposed SHR male (60.9%) pups. This coincided with an increased (47.0%) expression of a gene negatively regulated by T3, Odf4 suggesting local intracerebellar T3 deficiency. Blebbistatin mw Our data thus demonstrate a negative neurodevelopmental impact of perinatal TM exposure which appears to be both strain- and sex-dependent.”
“Arterial microanastomoses with small-caliber vessels, such as those with an internal diameter less than 0.2 mm, are susceptible to inadvertent twisting. A total of 20 supermicroanastomoses were performed in the superficial inferior epigastric artery (SIEA)-based flap model of ten 10-week old, 300- to 350-g male Sprague-Dawley rats. Two rats with 4 flaps comprised each experimental group: a negative control, Selleck ITF2357 a control with end-to-end SIEA arterial supermicroanastomosis, and 3 experimental groups (EAs), such as EA1, 2, and 3 with 90-, 180-, and 270-degree twisting supermicroanastomosis, respectively.

Each SIEA was clamped with a Superfine Vascular Clamp (S&T Co, Neuhausen, Switzerland) and anastomosed with 6 stitches. On postoperative day 10, the skin flap surface texture had no color change,

and skin necrosis was not found in any group within a 1.0-mm grid measurement in less than 1% of the whole skin flap surfaces. There were statistically significant differences between the groups in 4 criteria, such as cellular swelling, nuclear pleomorphism, nuclear swelling, and microvessel numbers. The pulsatility index was increased in the EA1 and EA2 on postoperative days 1 and 2, showing decrease in the similar preoperative value on postoperative day 10, but decreased pulsatility index I-BET151 mw was continuous in the EA3 during the postoperative day 10. The resistance index was significantly different between preoperative and postoperative day 10 especially in the EA2 and EA3. Ultramicroscopic findings in the EA3 group showed an increase in tunica media necrosis, convolution of the internal elastic lamina, and densely packed platelets, fibrins, and erythrocytes.”
“Background: We aimed to investigate the effects and dose dependency of aspirin on endothelial functions and prevalence of aspirin resistance in newly diagnosed hypertensive patients without previous drug therapy and development of cardiac complications. Hypothesis: Acetylsalicyclic acid improves endothelial function. Methods: Fifty-eight hypertensive patients and 61 healthy subjects in the control group were included in the study. Endothelial functions of the patient and control groups were evaluated with brachial artery examination.

5%) among cases of skin and soft tissue infections. S. aureus was also the second most frequently isolated pathogen from patients with lower respiratory tract infections (24.9% of cases) after Pseudomonas aeruginosa (30.5%). Resistance to oxacillin. was observed in 31.0% of S. aureus and the vast majority of oxacillin-resistant (MRSA) strains were also DNA Damage inhibitor resistant to clindamycin, ciprofloxacin and levofloxacin. Vancomycin, linezolid and daptomycin were all very active against S. aureus

strains tested (>99.9-100.0% susceptible), but daptomycin (MIC(50), 0.25 mu g/mL and MIC(90), 0.5 mu g/mL) was four- to eight-fold more potent than vancomycin (MIC(50) and MIC(90), of 1 mu g/mL) and linezolid (MIC(50), 1 mu g/mL and MIC(90), SU5416 Protein Tyrosine Kinase inhibitor 2 mu g/mL). Vancomycin resistance

increased significantly among enterococci during the study period, but it was restrict to only one medical center until 2007 and emerged in a second medical center in 2008. Daptomycin was the most active antimicrobial tested against enterococci in general (100.0% susceptible), followed by linezolid (99.9% susceptible), ampicillin (87.4%) and vancomycin (84.6%). In conclusion, daptomycin and linezolid showed excellent in vitro activity against contemporary Gram-positive organisms (3,907) collected in Brazilian hospitals monitored by the SENTRY Program, including MRSA, vancomycin-resistant enterococci (VRE) and other multidrug-resistant organisms. Although vancomycin resistance rates in Brazil appears to be relatively low compared to those reported in the USA, VRE has emerged and rapidly disseminated in some Brazilian medical centers.”
“Patients following laparoscopic adjustable gastric banding (LAGB) are generally advised to avoid liquid calories, opt for solids and refrain from drinking

with meals as this is believed to prolong satiety. The role of food consistency and satiety following LAGB is largely uninvestigated. The purpose of the study was to: (1) determine if food consistency impacts on post meal satiety in participants with well-adjusted LAGB and (2) compare the level of satiety achieved after consuming a solid versus a liquid meal between groups.

Twenty intervention (well-adjusted LAGB) and 20 control participants were recruited. All participants consumed three iso-caloric breakfasts that were randomised for nine mornings. Participants were asked to rate their satiety on visual analogue C188-9 chemical structure scales (VAS) at set times after the test meal. Areas under the curve (AUC) VAS scores were compared within and between groups.

Solids (bars) with or without water provided greater satiety than the liquids (shakes) for both groups. Drinking water with the bar did influence satiety in the intervention group. For the intervention group (LAGB), AUC VAS values for the bar with water were 77.4 +/- 11.2* and 72.4 +/- 16.7* for the controls.

Solid meals are more satisfying in both LAGB and non-LAGB individuals. However, a solid meal with accompanying water did not alter meal satiety.

We found that these probands shared similar

phenotypes, including selleck kinase inhibitor severe feeding difficulties, failure to thrive, and neurologic abnormalities with significant developmental delay. Further, they showed less phenotypic overlap with patients who had de novo truncating mutations in ASXL1.

Conclusion: We have identified truncating mutations in ASXL3 as the likely cause of a novel syndrome with phenotypic overlap with Bohring-Opitz syndrome.”
“Recurrent spontaneous abortion (RSA) is a multifactor and distressing disease. There are still approximately half of the RSA patients with cause not being identified to date. Accumulating studies have confirmed that genetic polymorphisms in glutathione S-transferases

(GSTs) were associated with the risk of recurrent spontaneous abortion. In this study, we aimed to investigate the relationship between the polymorphism of GSTA1, which is GSTA1 -69C/T (rs3957357), and the development of recurrent spontaneous abortion.

A case-control study of 127 cases with RSA and 112 ethnic and age matched women as controls was conducted. And measurement of Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) was performed to genotype all of samples in order to analyze the association between GSTA1 -69C/T (rs3957357) and the risk of RSA.

We found that the frequencies of genotypes between cases and controls have no significant S3I-201 in vivo difference (P = 0.908) and GSTA1 mutant allele GSTA1 -69 T was present at a frequency of 0.122 in case group, while in controls the frequency was 0.125 (P = check details 0.922).

The polymorphism of GSTA1 (rs3957357) may not be associated with the risk of recurrent spontaneous abortion in Chinese Han population.”
“To determine participant experience of exercise programs for nonspecific chronic low back pain (NSCLBP). Systematic reviews have concluded that exercise is

effective for decreasing pain and improving function in adults with NSCLBP. Participation is a key ingredient in exercise and patient’s experiences during these programs may be important in influencing outcomes.

Qualitative methods with three focus groups facilitated by an independent, experienced facilitator.

Eighteen people aged over 18 years were included. They had to speak, read and understand English and participated in an exercise program for NSCLBP. Each group was guided with a series of predetermined questions to elicit their experience of participation in exercise programs. Participants were encouraged to give personal opinions freely. Transcribed data were read independently by two researchers and analysed thematically with grounded theory.

Stigma emerged as a significant theme in all focus group transcripts. The results demonstrate that people with NSCLBP experience both subtle and overt stigmatization.

The clinical manifestations of neurocysticercosis (NCC) largely depend on the the host immune response against the parasite. NCC diagnosis is based upon neuroimaging studies (computerized tomography, magnetic resonance imaging) and antibody/antigen detection in the

serum and the cerebrospinal fluid.Anticysticercal therapy has been marked by an intense controversy. Randomized controlled trials evaluating the clinical benefit of treatment have yield conflicting data with some studies indicating a benefit and others failing to show a difference. Prevention strategies must rely on multiple approaches, tailoring each to the special features of the particular endemic area.”
“Aim: To study the outcome of biopsy-diagnosed cervical intraepithelial neoplasia (CIN) 2 in patients treated by loop electrosurgical excision procedure (LEEP) or cold knife cone biopsy (CKC).

Material MK-2206 mw and Methods: Patients (n = 131) were analyzed for histological results on LEEP/CKC specimen. Demographic and risk factors, referral cytology, high risk human papilloma virus (HR HPV) test and follow-up colposcopic clinic visits were studied.

Results: Excisional

specimens from LEEP/CKC demonstrated no CIN in 20 (15%), CIN 1 in 17 (13%), CIN 2 in 57 (44%) and CIN 3 in 37 (28%). No invasive cancers were identified. The referral Pap smear was high grade or possible high grade in 52 (40%), low grade in 59 (45%) Stem Cell Compound Library mouse and inconclusive in 20 (15%). Fourteen patients (11%) had positive excisional margins, eight of the 14 were tested for HR HPV infection before LEEP, and all were positive. Post-treatment HPV testing was performed at the 12-month visit in 6 of the 14 patients who had positive excision margins, and all 6 tested were negative. Two women (1.5%) with clear margins had recurrence of CIN 2, both tested positive for HR HPV after treatment.

Conclusion: Our data showed that a significant number of women (28%) with biopsy-diagnosed CIN 2 had CIN 1 or no dysplasia

on subsequent excisional biopsy. HM781-36B nmr The recurrence risk of high grade dysplasia in CIN 2 is low (1.5%). However, due to the high number of patients (72%) with high grade dysplasia at treatment biopsy, caution needs to be exercised when a conservative approach is adopted in the management of CIN 2.”
“Genomic imprinting and DNA methylation play an important role in mammalian development. Many cloned animals showed heterogeneous DNA methylation profiles. However, there are fewer reports in cloned lambs because of a lack of genomic imprinting information. In this study, we investigated DNA methylation patterns in CpG islands and differentially methylated regions of putative imprinted gene Peg10 and imprinted genes Dlk1, Igf2R and H19 in cloned lambs. Five organs from two cloned lambs died shortly after birth and two normal controls were investigated.

The whole kidneys contained Ba, Cd, Cr, Ga, Pb, Se, Sr and Tl at statistically greater concentrations than liver or muscle tissue from the same animal. Liver showed statistically greater concentrations of Ag, Co, Cu, Mn and

Mo than kidneys or muscle tissue, and muscle tissue was richer in Zn, when compared to the kidneys or liver. Cs and Rb were similarly distributed between all three tissue types, while V was less abundant in liver than kidneys or muscle tissue. There were significant associations between some metallic elements retained in Red Deer demonstrated by Principal Component Analysis (PCA) of the data set. In organ and muscle meats (kidneys, liver and muscle tissue considered together) the first principal component (PC1) was strongly influenced by positively correlated variables describing Se, Ba and Cd and negatively correlated variables describing Ag, Co, Cs, Mn, Pb. Tl and V; PC2, respectively, Selleckchem Pitavastatin check details by Cu, Mn and Mo (+) and Zn (-); PC3 by Ga (+) and PC4

by Sb (+). Selenium occurred in muscle tissue, liver and kidneys at median concentrations of 0.13, 0.19 and 4.0 mg/g dry weight, respectively. These values can be defined as marginally deficient (<0.6 mg Se/kg liver dw) or satisfactory (<= 3.0 mg Se/kg kidneys dw) for the amount required to maintain the Deer’s body condition and health, depending on the criterion for supplementation used. In terms of human nutritional needs, a relatively high selenium content of kidneys can be beneficial. The muscle meat, liver and kidneys of Red Deer can be considered as a very good source of essential Co, Cr, Cu, Mo, Mn, Se and Zn in the human diet. Lead is generally considered as toxic, and the concentrations found in Red Deer (via the food chain intake) were well below SGC-CBP30 solubility dmso the European Union tolerance limit. Pb from the lead bullets can always create food hygienic problem, if not well recognized during sanitary inspection, and

this was noted for one muscle meat sample in this study (5% surveyed). There is no tolerance limit of Cd in game animal meats. The median values of Cd noted in fresh muscle tissue, liver and whole kidneys were 0.07, 0.18, and 3.3 mg/kg wet weight, respectively. Cd exists as a chemical element present at trace levels in plants and mushrooms in Deer’s food chain in background (uncontaminated) areas. When these are consumed by the Deer, the amount of Cd sequestered with metallothioneins and retained in the organ and muscle meat in this study is low enough to be considered safe for human consumption. (C) 2011 Elsevier Ltd. All rights reserved.”
“The post-translational modification of serine and threonine residues of proteins by O-linked -N-acetylglucosamine (O-GlcNAc) is highly ubiquitous, dynamic and inducible. Protein O-GlcNAcylation serves as a key regulator of critical biological processes including transcription, translation, proteasomal degradation, signal transduction and apoptosis.

5%, multiple small nodules in 10%, and diffuse ground glass appearance in 2.5% of all cases. Air bronchograms were present in 45%, cavitations in 12.5%, and pleurisy in 7.5% of all lesions. OP occurred in

association with infections (53%), Elacridar cost neoplastic diseases (23%), both (7%), and other disorders (7%). A cryptogenic origin of OP was in 10% of all cases.

OP mostly manifested with mild-to-moderate respiratory symptoms and single or multiple lung infiltrates. OP varied in clinical and radiological forms. OP associated mostly with infection and/or neoplasm in our patients. Other reasons and cryptogenic origins of the disorder were rare.”
“A retrospective study of 81 patients with low-grade astrocytoma (LGA) comparing the efficacy of aggressive versus less aggressive surgery in eloquent and non-eloquent brain areas was conducted. Extent of surgical resection was analyzed to assess overall survival (OS) and progression-free JPH203 nmr survival (PFS). Degree of tumor resection was classified as gross total resection (GTR), subtotal resection (STR) or biopsy. GTR, STR and biopsy in patients with tumors in non-eloquent areas were performed in 31, 48 and 21% subjects, whereas in patients with tumors in eloquent areas resections were 22.5, 35 and 42.5%. Overall survival was 4.7 and

1.9 years in patients with tumors in non-eloquent brain areas submitted to GTR/STR and biopsy (p=0.013), whereas overall survival among patients with tumors in eloquent area was 4.5 and 2.1 years (p=0.33). Improved outcome for adult patients with LGA is predicted by more aggressive surgery in both eloquent and non-eloquent brain areas.”
“Purpose of review

The autonomic nerve system is a potentially potent modulator of the initiation and perpetuation of atrial fibrillation. This review will briefly summarize the

neural mechanisms of atrial fibrillation.

Recent findings

Complex interactions exist between the sympathetic and parasympathetic nervous system on the atrial electrophysiologic properties. Direct autonomic recordings in canine models demonstrated simultaneous sympathovagal discharges are the most common triggers of paroxysmal atrial tachycardia and paroxysmal atrial fibrillation. Also, intrinsic cardiac autonomic PI3K inhibitor nerve can serve as a sole triggering factor for the initiation of atrial fibrillation. Modulation of autonomic nervous system (ANS) by electrical stimulation has been tried as a treatment strategy clinically and experimentally. Recent studies showed that autonomic nervous system modulation can suppress the stellate ganglion nerve activity and reduce the incidence of paroxysmal atrial tachyarrhythmias in ambulatory dogs.

Summary

The autonomic nerve system influences the initiation and perpetuation of atrial fibrillation.

Necropsy findings included moderate to marked atrophic enteritis associated with numerous intraepithelial and fewer extracellular coccidial life stages. Sporulated oocysts isolated from feces were consistent with Eimeria furonis. A PCR assay was performed on formalin-fixed, paraffin-embedded sections of intestine for the gene encoding the

small subunit of rRNA yielded products with sequences identical to those described for E furonis.

Treatment and Outcome-Supportive MAPK inhibitor care and treatment with sulfadimethoxine over the course of these outbreaks was palliative, but long-term treatment was required and failed to completely eradicate infection as identified by the subsequent finding of oocysts in fecal samples.

Clinical Relevance-Enteric coccidiosis due to infection with E furonis has typically been reported to be subclinical rather than to cause severe gastrointestinal disease in ferrets. This report indicated that infection with E furonis may have contributed to severe enteric disease with high morbidity and mortality rates in 3 densely populated, dynamic HDAC inhibitors cancer groups of ferrets. Furthermore, long-term treatment with anti-coccidials may be required in outbreak situations, but may be ineffectual in completely

eradicating infection. (J Am Vet Med Assoc 2011;239:1584-1588)”
“The physiological and molecular mechanisms associated with acclimation and survival have been examined in four Ribes genotypes displaying differential cryotolerance. Changes in DNA methylation, nucleic acid and nucleoside composition were determined during acclimation and recovery of in vitro shoot-meristems from cryopreservation. DNA methylation was induced in the tolerant genotype, while demethylation was evident in sensitive genotypes. This response initially occurred during sucrose simulated acclimation, with progressive changes as shoots recovered from successive stages of the encapsulation-dehydration protocol. These methylation patterns existed in the initial vegetative cycle but regressed to control values following subculture, indicating

the changes in DNA methylation to be a reversible epigenetic mechanism. RNA levels indicating transcriptional activity during the acclimation of nodal tissue are inversely linked to methylation changes, where DZNeP inhibitor activity appears to be up-regulated in the cryosensitive genotypes. Conversely, cryopreserved shoots show increased levels of both RNA and DNA methylation in the cryotolerant genotypes. Other nucleosides show post-transcriptional activity corresponds with tolerance during acclimation and cryopreservation. These observations connect physiological attributes to differential molecular changes in Ribes, the implications of which are discussed in relation to cryopreservation-induced apoptosis and genetic stability. (C) 2008 Elsevier Masson SAS. All rights reserved.

When she entered puberty, treatment with a luteinizing-hormone-releasing hormone agonist was initiated and growth hormone was added. Almost 5 years later a left adrenalectomy was also performed.

Thereafter, complete disease remission was observed, the patient’s growth accelerated and her osteopenia reversed.”
“BACKGROUND: Previous studies have found no association between graft ischemic time (IT) and survival in pediatric heart transplant (HTx) recipients. However, previous studies were small or analyzed risk only at the extremes of IT, where observations are few. We sought to determine whether graft IT is independently associated with graft survival in a large cohort of children with no a priori assumptions about where the risk threshold may lie.

METHODS: All children aged <18 years in the U.S. undergoing primary this website HTx (1987 to 2008) were included. The primary end point was graft loss (death or retransplant) within 6 months. Multivariate analysis was performed to analyze the association between graft

IT and graft loss within 6 months after transplant. BIBW2992 cost A secondary end point of longer-term graft loss was assessed among recipients who survived the first 6 months after transplant.

RESULTS: Of 4,716 pediatric HTxs performed, the median IT was 3.5 hours (interquartile range, 2.7-4.3 hours). Adjusted analysis showed that children with an IT > 3.5 hours were at increased risk of graft loss within 6 months after transplant (hazard ratio,

1.3; 95% confidence interval, 1.1-1.5; p = 0.002). Among 6-month survivors, IT was not associated with longer-term graft loss.

CONCLUSIONS: IT beyond 3.5 hours is associated with a 30% increase in risk of graft loss within 6 months in pediatric HT recipients. Although the magnitude of risk associated with IT is small compared with the risk 发现更多 associated with recipient factors, these findings may be important during donor assessment for high-risk transplant candidates. J Heart Lung Transplant 2011;30:1244-9 (C) 2011 International Society for Heart and Lung Transplantation. All rights reserved.”
“Maternal adrenal cortical carcinoma in pregnancy is rare. We report a case of an infant born to a mother with a history of adrenal cortical carcinoma. The pregnancy was complicated by fetal exposure to mitotane and dexamethasone. Despite the potential teratogenic exposures, there was no evidence of adrenal dysfunction in the infant. Growth and development at 12 months of age are normal and prognosis appears favorable. The long-term impact of fetal exposure to mitotane and glucocorticoid requires further investigation.”
“BACKGROUND: Extracorporeal membrane oxygenation (ECMO) provides hemodynamic support in refractory cardiogenic shock and may be used after heart transplantation for primary graft dysfunction or rejection. We hypothesized that survival after ECMO support is contingent upon patient selection.