Long-term chlorimuron-ethyl application reduced the abundance of soil culturable nitrogen-fixing, ammonia-oxidizing, and denitrifying bacteria. Moreover, chlorimuron-ethyl decreased the diversity of nitrogen-fixing and ammonia-oxidizing bacteria but promoted that of denitrifying bacteria. Chlorimuron-ethyl restrained some uncultured nitrogen-fixing bacteria, ammonia-oxidizing bacteria Nitrosospira sp. cluster 3a and 3d, and some novel or putative denitrifying

bacteria. The nitrogen-fixing bacteria were closely related to Bradyrhizobium sp., ammonia-oxidizing bacteria Nitrosospira sp. cluster 3b and 3c, and most denitrifying bacteria were resistant to chlorimuron-ethyl. VX-680 There was a negative correlation between the nitrification potential and the LCL161 residual amount of soil chlorimuron-ethyl (R-2 = 0.88, n = 3, P < 0.05). Therefore, long-term application of chlorimuron-ethyl in the continuously cropped soybean field could seriously disturb soil N-transforming communities, and might impact soybean soil biological quality and soybean growth. Further studies should address rational amendment models of this herbicide to reduce the possible ecological risks of long-term application of this herbicide to soybean fields.”
“Malignant pleural mesothelioma (MPM) remains an aggressive thoracic malignancy associated

with poor prognosis. There is no standard treatment regimen, and particularly, the impact of radical surgery remains controversial. The main goal of our retrospective single-centre study was to evaluate JIB 04 the surgical and non-surgical treatment modalities applied at our division regarding their effect on the patient’s survival.

During the last decade, 82 patients with histologically confirmed MPM were treated at our division. The complete clinical records of 61 patients were eligible for statistical evaluation.

There were 14 women (23%) and 47 men (77%) with a mean age of 63.7 years. Epitheloid subtype was

found in 48 patients (78.7%), sarcomatoid in 3 (4.9%) and biphasic in 10 (16%). Surgery as the first treatment modality was performed in 44 patients (72.1%). Pleurectomy/decortication was done in 28 cases (45.9%), extended pleurectomy/decortication was performed in 13 (21.3%) and extrapleural pneumonectomy in 3 (4.9%). Additional intraoperative photodynamic therapy was administered in 20 patients, 34 underwent chemotherapy (55.7%) and 12 had radiotherapy (19.7%). Mean survival time for the collective was 18.3 months. Five-year survival was 17% in the epitheloid histology group, where patients treated with chemotherapy alone yielded a significant increase in survival (P = 0.049), and those with other subtypes survived for a maximum of 20.6 months.

Chemotherapy and pleurectomy/decortication can extend the survival time of patients with MPM remarkably.

Summary

Despite advances in our understanding, ALF remains a cause of significant mortality in children and adults because of the absence of curative Selleck Entinostat medical therapy. Hence, only emergency liver transplantation is reliably life-saving.

There is an urgent need for better understanding of the pathogenesis of ALF caused by different causes, of genetic susceptibility, development of validated prognostic indicators and application of this knowledge to devise new therapeutic strategies for testing in appropriately powered, randomized controlled trials.”
“Background: The surge in biomarker development calls for research on statistical evaluation methodology to rigorously assess emerging biomarkers and classification models. Recently, several authors reported the puzzling observation that, in assessing the added value of new biomarkers to existing ones in a logistic regression model, statistical significance of new predictor variables does not necessarily translate into a statistically significant increase in the area under the ROC curve (AUC). Vickers et al. concluded that this inconsistency is because

AUC “”has vastly inferior statistical properties,”" i.e., it is extremely conservative. This statement is based on simulations that misuse the DeLong et al. method. Our purpose is to provide a fair comparison of the likelihood ratio (LR) test and the Wald test versus diagnostic accuracy (AUC) tests.

Discussion: We present a test to compare ideal AUCs of nested NU7441 linear

discriminant functions via an F test. We compare it with the LR test and the Wald test for the logistic regression model. The null hypotheses of these three tests are equivalent; however, the F test is an exact test whereas the LR test and the Wald test are asymptotic tests. Our simulation shows that the F test has the nominal type I error even with a small sample size. Our results also indicate that the LR test and the Wald test have inflated type I errors when the sample size is small, while the type I error converges to the nominal value asymptotically with increasing sample size as expected. GDC-941 We further show that the DeLong et al. method tests a different hypothesis and has the nominal type I error when it is used within its designed scope. Finally, we summarize the pros and cons of all four methods we consider in this paper.

Summary: We show that there is nothing inherently less powerful or disagreeable about ROC analysis for showing the usefulness of new biomarkers or characterizing the performance of classification models. Each statistical method for assessing biomarkers and classification models has its own strengths and weaknesses. Investigators need to choose methods based on the assessment purpose, the biomarker development phase at which the assessment is being performed, the available patient data, and the validity of assumptions behind the methodologies.

“
“OBJECTIVE: To estimate the effect of energy-based vessel sealing compared with suturing in women undergoing vaginal hysterectomy with respect to surgical outcomes.

DATA SOURCES: selleck compound We searched the Cochrane Central Register of Controlled Trials, MEDLINE, and EMBASE.

We also screened references from relevant articles and searched trial registries and other sources of unpublished literature.

METHODS OF STUDY SELECTION: Randomized controlled trials comparing the use of energy-based vessel sealing devices with traditional suturing of vascular pedicles for vaginal hysterectomy, in women of any age, were included.

TABULATION, INTEGRATION, AND RESULTS: Two authors completed independent data extraction and bias assessment of included articles. We used the Grading of Recommendations Assessment, Development and Epigenetic inhibitor order Evaluation methodology to assess bias across studies at

the outcome level. Data were pooled based on the random effects model. Seven studies met inclusion criteria (n = 662). Energy-based vessel sealing devices decreased operative time by a mean of 17.2 minutes (seven studies, 662 patients; 95% confidence interval [CI] 7.5-27.0) blood loss by a mean of 47.7 mL (five studies, 437 patients; 95% CI 15.5-79.9), drop in hemoglobin by 0.3 g/dL (two studies, 291 patients; 95% CI 0.1-0.6), and postoperative hospital stay by 0.25 days (five studies, 554 patients; 95% CI 0.13-0.37). There was no increase in the rate of complications for energy-based vessel sealing compared with traditional suturing.

CONCLUSION: This review suggests that energy-based vessel sealing devices may decrease operating time, blood loss, and hospital stay. There was no difference in complication rate and no studies investigated mortality or quality of life.

SYSTEMATIC REVIEW REGISTRATION: PROSPERO, http://www.crd.york.ac.uk/PROSPERO, Roscovitine research buy CRD42011001124. (Obstet Gynecol 2011;118:1127-36) DOI: 10.1097/AOG.0b013e3182324306″
“Underlying molecular

genetic mechanisms of diseases can be deciphered with unbiased strategies using recently developed technologies enabling genome-wide scale investigations. These technologies have been applied in scanning for genetic variations, gene expression profiles, and epigenetic changes for oral and craniofacial diseases. However, these approaches as applied to oral and craniofacial conditions are in the initial stages, and challenges remain to be overcome, including analysis of high throughput data and their interpretation. Here, we review methodology and studies using genome-wide approaches in oral and craniofacial diseases and suggest future directions. Oral Diseases (2013) 19, 111-120″
“This study compared the effects of external hex, internal octagon, and internal Morse taper implant-abutment connections on the peri-implant bone level before and after the occlusal loading of dental implants.

The perioperative morbidity rate was 6.5% and mortality was 1.9%. Overall survival was 41.2% and disease-free survival 31.5% at 5 years. Survival at 5 years was better for patients with metachronous than for those with synchronous lesions (60.9% vs 28.1%; p<0.05). There were no significant differences in terms of long-term survival between patients

with synchronous metastases that were excised simultaneously or with a delay of 3-6 months (p=n.s.). Site of the primary tumor, Dukes stage, number of metastases and type of resection did not influence survival. A favorable survival trend was observed in those patients who underwent both neoadjuvant and adjuvant chemotherapy. The overall survival rate at 5 years was 45.3% for patients undergoing a second www.selleckchem.com/products/ulixertinib-bvd-523-vrt752271.html hepatic resection and 50% for those with a third or a fourth hepatic resection. Liver resection

remains the “”gold standard”" for the treatment of patients with colorectal liver metastases, with metachronous type having a better outcome than synchronous. Simultaneous or delayed surgery for synchronous metastases does not influence prognosis. Iterative resection is very encouraging and justifies an aggressive surgical approach.”
“In this study we evaluate the oncological and functional results of the largest cohort of patients in China treated by laparoscopic radical prostatectomy (LRP) and with at least 3 years of follow-up. 126 inconsecutive patients (range 56-78 click here years, median 62.5) who had

an LRP were retrospectively analyzed. The mean prostate specific antigen level and Gleason score was 13.4 ng mL(-1) and 6.4, respectively. Twenty-seven patients had unilateral or bilateral nerve preservation and 29 had pelvic lymphadenectomy. Multivariate analysis was used to adjust for differences in clinical and pathological features when comparing the risk for biochemical progression-free survival (bPFS). Urinary continence was assessed by incontinence questionnaire and erectile function by the Sexual Health Inventory for Men score. The mean operative duration was 250 min and blood loss 354 mL. Five patients received blood transfusion and nine had complications, including rectal injury (two), ureteral PD-L1 inhibitor injury (one), active bleeding (one), bladder neck stenosis (two), paralytic ileus (one), subcutaneous hematoma (one) and port-site hernia (one). The overall positive surgical margin rate was 20.6% and correlated with pathological stage and Gleason score respectively (P = 0.03, P < 0.001 respectively). All patients had >= 3 years of follow-up (range 3-6.75 years, mean 4.6, median 4.75). At 3 years of follow-up, the overall survival rate was 100% and the bPFS was 81.0% in all patients; 124 patients (98.4%) were continent; 22 of 27 patients (81.5%) who underwent nerve preservation retained erectile function. Our series confirms that LRP is an effective, safe and precise technique at Chinese institution.”
“Study Design. A structured questionnaire.

Objective.

Radial artery blood samples were collected to quantify plasma histamine concentrations 1min before and 1, 3, and

5min after administration of the relaxant. Mean arterial pressure (MAP), heart rate (HR), and skin flushing were recorded at the same time.

ResultsNo significant decreases in plasma histamine concentrations were observed between groups; however, more stable MAP and HR and less skin flushing were observed in DXM group participants compared with individuals in the mivacurium group (P<0.05). By contrast, children in the promethazine group had significantly decreased plasma histamine concentrations and stable MAP and HR (without a significant increase in HR) compared with patients in mivacurium group. In addition, skin flushing was significantly decreased compared with that observed in the rocuronium group (P<0.05).

ConclusionsPretreatment with promethazine significantly decreased mivacurium-induced histamine release in children p38 MAP Kinase pathway and provided stable hemodynamics during administration of anesthesia.”
“A two-port GaN nanowire (NW) device with one Schottky contact and one Ohmic contact was characterized up to 10 GHz using on-wafer microwave measurements. In addition to the measurement of the broadband response, two additional applications of microwave measurements

are introduced: (1) the capability to distinguish a Schottky-type contact from an Ohmic contact based on the reflected broadband signals (S(11) and S(22)) and (2) Selleckchem Cl-amidine the measurement of a capacitance voltage (CV) curve for a Schottky contact to a bundle of a few NWs. The junction capacitance of the Schottky contact is determined at various bias voltages by fitting the broadband

response with a microwave circuit model. The carrier concentration is estimated from the resulting CV curve to be 5.3 X 10(18)/cm(3) and the Schottky barrier height is estimated to be 0.89 eV. (c) 2010 American Institute of Physics. [doi:10.1063/1.3428391]“
“In this article, a new class of “”green”" solvent ionic liquid (IL) was employed to improve the dye-ability of wool. GDC-0068 order The physical and chemical properties of the IL-treated wool, such as surface morphology, wettability, and tensile strength were first analyzed, and then the dyeing properties of IL-treated wool were investigated in terms of dyeing rate, dyeing exhaustion at equilibrium, color depth, and color fastnesses. The scanning electron microscope (SEM) images showed eroded marks on IL-treated wool fiber surfaces. The water contact angle of the fabric treated with IL at 100 degrees C decreased from 118.6 degrees to 106.4 degrees. The tensile strength of IL-treated wool fibers was slightly decreased when the treating temperature was less than 100 degrees C. Dyeing kinetics experiments revealed that the IL treatments greatly increased initial dyeing rate, shortened half-dyeing time, and time to reach dyeing equilibrium.

However, our results did not show any impairment of learning of extinction after the administration of alcohol. Behavioural as well as attentional responses indicated extinction of conditioned responses for both experimental groups.

Conclusions: These findings suggest that alcohol at LY2606368 a dose that impairs performance in a task of inhibitory control does not impair learning of extinction. (C) 2009 Elsevier Ireland Ltd. All rights reserved.”
“Five mutant forms of glucoamylase (GA) from the filamentous fungus Aspergillus awamori with artificial disulfide bonds (4D-G137A\A14C,

6D-A14C\Y419C\G137A, 10D-V13C\G396C, 11D-V13C\G396C\A14C\Y419C\G137A, and 20D-G137A\A246C\A14C) were constructed using molecular modeling simulations and experimentally tested for thermostability. The introduction of two additional disulfide bonds between its first and thirteenth alpha-helices and that of the loop located close to a catalytic residue-E400-made

it possible to assess the effects IGF-1R inhibitor of disulfide bridges on protein thermostability. The mutant proteins with combined amino acid substitutions G137A\A14C, V13C\G396C\A14C\Y419C\G137A, and G137A\A246C\A14C showed higher thermal stability as compared to the wild-type protein. At the same time, new disulfide bridges in the mutant A14C\Y419C\G137A and V13C\G396C proteins led to the destabilization of their structure and the loss of thermal stability.”
“A series of organic-inorganic hybrid thermosensitive,gels with three different structures were prepared from N-isopropylacrylamide

OSI-906 price (NIPAAm), and N, N’-methylenebisacrylamide (NMBA) and tetraethoxysilane (TEOS) [N-IPN]; NIPAAm 3-(trimethoxysilyl) propyl methacrylate (TMSPMA) as coupling agent and TEOS [NT-IPN]; and NIPAAm, TMSPMA, and TEOS [NT-semi-IPN] by emulsion polymerization and sol-gel reaction in this study,. The effect of different gel structures and coupling agent oil the swelling behavior, mechanical properties, and morphologies of the present gels was investigated. Results showed that the properties of the gels would be affected by the gel networks such is IPN or semi-IPN and with or without existence of TMSPMA as the bridge chain between networks. The NT-semi-IPN gel had higher swelling ratio and faster diffusion rate because poly(NIPAAm) moiety in the semi-IPN gels was not restricted by NMBA network. However, the IPN gels such as N-IPN and NT-IPN had good mechanical properties and lower swelling ratio, but had a poor thermosensitivity due to the addition of coupling agent, TMSPMA, into the gel system that resulted in denser link between organic and inorganic components. The morphology showed that IPN gels had partial aggregation (siloxane domain) and showed some denser phases. (c) 2008 Wiley Periodicals, Inc.

The sex ratio, male/female was 1:4.4. The most popular aetiology for coccygodynia was direct trauma in 270 patients. 504 of the patients reported an excellent/good outcome following the procedure. AZD6094 Protein Tyrosine Kinase inhibitor There were 9 deep and 47 superficial infections. Other complications included two haematomas, six delayed wound healings and nine wound dehiscence. The overall complication rate was 11%. Patients with history of spinal or rectal disorders, as well as idiopathic or with compensation

issues, had less predictable outcome than those with history of trauma or childbirth. Coccygectomy can provide pain relief to as high as 85% of the cases. The most common reported complication was wound infection.”
“By

the XRD analysis the structure was established of 1-(7,8-dimethyl-4-chloroquinolin-2-yl)-2-[3,5-di(tert-butyl)-6-oxo-6H-pyran-2-yl]ethane-1,2-dione formed as a result of the oxidation of 3,5-di(tert-butyl)-6-[(Z)-2-(quinolin-2-yl)-1-hydroxyethen-1-yl]pyran-2-ones. By the cyclic voltammetry the oxidation of 1-(quinolin-2-yl)-2-(pyran-2-yl)ethane-1,2-dione derivatives was shown to proceed in two stages.”
“Objective/Hypothesis: The aim of this study was to assess the tissue response to Gore-Tex (expanded polytetrafluoroethylene) in rats and compare the results of surgical placement modalities.

Study Design: Prospective animal study.

Materials and Methods: Experiments were performed in 18 young Sprague-Dawley rats that were divided into 3 groups. Gore-Tex patches were implanted subcutaneously over the BLZ945 price periosteum in the first group and JNK-IN-8 mouse under the periosteum in the other groups. Gore-Tex was immersed in an antibiotic-containing solution in the third group. All animals were killed 4 weeks after the procedure. The tissue samples were stained with hematoxylin and eosin stain and evaluated using a light microscope.

Results: The Gore-Tex patches were displaced and not observed at the originally implanted sites in the first group. The Gore-Tex patches were observed at the originally implanted sites in the other groups. In group

1, edema and inflammation were prominent. In the second group, ossification was detected in 5 rats and foreign-body reaction and edema were identified in 1 rat. In the third group, all of the rats were found to have developed ossification, but no inflammatory reactions were observed.

Conclusions: The results suggest that implanting synthetic graft materials immersed in an antibiotic solution at the subperiosteal plane provides better stabilization and low complication rates.”
“Objectives: To compare microhardness along the root canal post space of two resin cements in different shades and a dual-cure resin core material.

Study Design: Root canals of 21 bovine incisors were prepared for post space. Translucent posts (X.

eNO levels were analysed using a validated handheld analyser.

RESULTS: eNO levels among TB patients (median 115 parts per billion [ppb], interquartile range [IQR] 10-20) were equal to those among construction firm workers (15 ppb, IQR 12-19, P = 0.517) but higher than those among hospital workers (8.5 ppb, IQR 5-12.5, P < 0.001). Taking the hospital workers as the comparison group, best performance as a diagnostic tool was at a cut-off of 10 ppb, with sensitivity 78% (95% CI 68-86) and specificity 62% (95% CI 47-75). Test characteristics could be optimised to 84% SB273005 in vivo vs. 67% by excluding individuals who had recently smoked or consumed alcohol.

CONCLUSION: While eNO measurement

has limited value in the direct diagnosis of pulmonary TB, it may be worth developing and evaluating as a cost-effective replacement of chest X-ray in screening algorithms of pulmonary TB where X-ray is not available.”
“Mammography has been the primary screening test for early breast cancer for more than five decades, but conventional mammography imaging continues to have limitations in sensitivity and specificity. selleck kinase inhibitor Digital mammography detects some cases of cancer that are not identified by film mammography,

but overall detection is similar for many women. Digital breast tomosynthesis offers the potential to overcome one of the primary limitations of mammography, which is the inability to image overlapping dense normal breast tissue. Clinical data suggest that digital mammography with tomosynthesis produces a better image, improved accuracy,

and lower recall rates compared with digital mammography alone. Further study will be necessary to confirm whether digital mammography with tomosynthesis Vorinostat in vitro is a cost-effective approach, capable of replacing digital mammography alone as the first-line screening modality of choice for breast cancer screening.”
“SETTING: Effective tuberculosis (TB) screening should be performed before anti-tumour necrosis factor alpha (TNF-alpha) treatment in rheumatoid arthritis (RA). The usefulness of the tuberculin skin test (TST) and Quanti-FERON (R)-TB Gold (QFT-G) for detecting latent tuberculosis infection (LTBI) is limited.

OBJECTIVE: We tested the diagnostic performance of interferon-gamma (IFN-gamma) inducible protein 10 (IP-10) and IFN-gamma for detecting LTBI in RA patients receiving anti-TNF-alpha treatment.

DESIGN: IP-10 levels were determined by enzyme-linked immunosorbent assay in 56 RA patients and 18 active TB patients. TST was performed using the Mantoux method and QFT-G was performed by measuring IFN-gamma levels in whole blood treated with TB-specific antigens.

RESULTS: Twenty-four (42.9%) TST-positive patients were defined as having LTBI. Significantly higher levels of baseline, early secretory antigenic target 6 (ESAT-6) and culture filtrate protein 10 (CFP-10) stimulated IP-10 were observed in active TB patients (median 209.9 pg/ml, 899.0 pg/ml and 880.

4%) of them received a pre-emptive transplantation. For the nonpre-emptive patients, mean Protein Tyrosine Kinase inhibitor time on pretransplant dialysis was 3.4 +/- 3.2 years. Pretransplant factors independently related to pre-emptive transplantation were year of transplantation, centre and recipients characteristics: gender, diabetes history, blood group and donor age. Patients with pretransplant dialysis were three times more likely to have delayed graft function than pre-emptive transplant patients, and were 10 times more likely to receive post-transplant dialysis. Five-year patient survival was 92.9%. Five-year graft survival was 89.0%. Neither pre-emptive transplantation nor

time on dialysis was significantly associated with patient and/or graft survival.”
“Background: Due to demographic change, the advanced elderly represent the fastest growing population group in Europe. Health problems tend to be frequent and increasing with age within this cohort.

Aims of the study: To describe and compare health status of the elderly population in

six European countries and to analyze the impact of socio-demographic variables on health.

Methods: In the European Study of the Epidemiology of Mental Disorders (ESEMeD), representative non-institutionalized population samples completed the EQ-5D MCC950 clinical trial and Short Form-12 (SF-12) questionnaires as part of personal computer-based home interviews in 2001-2003. This study is based on a subsample of 1659 respondents aged >= 75 years from Belgium (n = 194), France (n = 168), Germany (n = 244), Italy (n = 317), the Netherlands (n = 164) and

Spain (n = 572). Descriptive statistics, bivariate-(chi-square tests) and multivariate methods (linear regressions) were used to examine differences in population health.

Results: 68.8% of respondents reported problems in one or more EQ-5D dimensions, most frequently pain/discomfort (55.2%), followed by mobility (50.0%), usual activities (36.6%), self-care (18.1%) and anxiety/depression (11.6%). The proportion of respondents reporting Kinesin inhibitor any problems increased significantly with age in bivariate analyses (age 75-79: 65.4%; age 80-84: 69.2%; age >= 85: 81.1%) and differed between countries, ranging from 58.7% in the Netherlands to 72.3% in Italy. The mean EQ VAS score was 61.9, decreasing with age (age 75-79: 64.1; age 80-84: 59.8; age >= 85: 56.7) and ranging from 60.0 in Italy to 72.9 in the Netherlands. SF-12 derived Physical Component Summary (PCS) and Mental Component Summary (MCS) scores varied little by age and country. Age and low educational level were associated with lower EQ VAS and PCS scores. After controlling for socio-demographic variables and reported EQ-5D health states, mean EQ VAS scores were significantly higher in the Netherlands and Belgium, and lower in Germany than the grand mean.

Conclusions: More than two thirds of the advanced elderly report impairment of health status. Impairment increases rapidly with age but differs considerably between countries.

81 to 0.87 for sum PCBs). Significant differences

in concentrations and profiles of OHCs were found between different primary feathers, indicating that the accumulation of OHCs in feathers varies over the moulting period (maximum three years). Washing of feathers with an organic solvent (acetone) resulted in a significant decrease in the measured concentrations of OHCs in feathers. However, our results indicated that preen oil is probably not the only contributor to the external contamination that can be removed by washing with acetone. Possibly dust and other particles may be of importance and may be sticking to BVD-523 solubility dmso the preened feathers. Rectrices washed only with water showed high and significant correlations with concentrations in muscle and preen oil as well. Washing with acetone therefore does not seem to be of great influence when relating to internal tissue concentrations. We recommend washing feathers only with distilled water in order to remove dirt and dust particles before analysis. (C) 2011 Elsevier Ltd. All rights reserved.”
“The aim of this study was to investigate the association between caffeine consumption and headache type and frequency in the general adult population.

The results were based on cross-sectional data from 50,483 (55%) out of 92,566 invited inhabitants aged a parts per thousand yen20 years who participated in the Nord-Trondelag Health Survey. In the multivariate analyses, adjusting for age, gender, smoking, and level of education as confounding factors, a weak but significant association (OR = 1.16, 95% CI 1.09-1.23) was found KU 55933 between high caffeine consumption and prevalence of infrequent headache. In contrast, headache > 14 days/month was less

likely among individuals with high caffeine consumption compared to those with low caffeine consumption. The results may indicate that high caffeine consumption changes chronic headache into infrequent headache due to the analgesic properties of caffeine. Alternatively, chronic headache sufferers tend to avoid intake of caffeine to not aggravate their headaches, whereas individuals with infrequent headache are less aware that high caffeine CH5183284 concentration use can be a cause.”
“Josef Jadassohn was a pioneering dermatologist who influenced the development of his specialty in many ways. He introduced the patch test for detection of hypersensitivity reactions, gave original descriptions of several entities, such as nevus sebaceous, granulosis rubra nasi, and pachyonychia congenita, and edited the Handbuch der Haut- und Geschlechtskrankheiten, the most comprehensive textbook of dermatology ever published. Moreover, Jadassohn left a phalanx of distinguished students, including Felix Lewandowsky, Wilhelm Lutz, Max Jessner, Hans Biberstein, Hermann Pinkus, and Marion B. Sulzberger.